Optogenetics: Applications in psychiatric research

Recently, optogenetic techniques have emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics results from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advanta...

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Bibliographic Details
Published in:Psychiatry and clinical neurosciences 2017-06, Vol.71 (6), p.363-372
Main Authors: Shirai, Fukutoshi, Hayashi‐Takagi, Akiko
Format: Article
Language:English
Subjects:
action potential
Animals
circuit‐centric therapeutics
Gene expression
Genetic engineering
Genetics
Humans
Information processing
Light intensity
Nervous system
neuronal network
Neurosciences - methods
opsins
Optics
optogenetics
Optogenetics - methods
Optogenetics - trends
Psychiatry - methods
Psychiatry - trends
Reviews
Wavelength
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Summary:Recently, optogenetic techniques have emerged as a method to optically manipulate molecular and cellular events in target cells both in vitro and in vivo. Optogenetics results from the fruitful combination of optics and genetic engineering, maximizing the advantages of each discipline. These advantages are optical control through the manipulation of wavelength and light intensity on the millisecond timescale, and specific gene expression and gene product trafficking with subcellular precision. This kind of fine‐tuning cannot be achieved using traditional methods. Therefore, optogenetic techniques have brought a revolution to neuroscience. In this review, we provide a concise summary of the history and recent advances of optogenetics, focusing in particular on applications for psychiatric research.
ISSN:1323-1316
1440-1819
DOI:10.1111/pcn.12516