IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway

Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells....

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Bibliographic Details
Published in:Immunology letters 2017-04, Vol.184, p.67-75
Main Authors: Lee, Seung Hoon, Jhun, JooYeon, Byun, Jae-Kyung, Kim, Eun-Kyung, Jung, KyoungAh, Lee, Ji Eun, Choi, Jong Young, Park, Sung-Hwan, Cho, Mi-La
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Adipocytes - metabolism
Adipogenesis
Allergy and Immunology
Animals
Biomarkers
Cell Differentiation
Cell Line
Cytokines - genetics
Cytokines - metabolism
Disease Models, Animal
Fatty Liver - genetics
Fatty Liver - immunology
Fatty Liver - metabolism
Fatty Liver - pathology
Gene Expression
I-kappa B Kinase - metabolism
IL-17
Immunomodulation
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Inflammation Mediators
Interleukin-17 - genetics
Interleukin-17 - metabolism
Macrophages - immunology
Macrophages - metabolism
Male
Mice
Mice, Knockout
Obesity
Obesity - genetics
Obesity - immunology
Obesity - metabolism
Obesity - pathology
Protein-Serine-Threonine Kinases - metabolism
Signal Transduction
TBK1
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Description
Summary:Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2017.02.004