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IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway
Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells....
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| Published in: | Immunology letters 2017-04, Vol.184, p.67-75 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c480t-98b2a1d678fc526062dc2ce9704c334c560b06620bde5c080de33f676beed1293 |
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| cites | cdi_FETCH-LOGICAL-c480t-98b2a1d678fc526062dc2ce9704c334c560b06620bde5c080de33f676beed1293 |
| container_end_page | 75 |
| container_issue | |
| container_start_page | 67 |
| container_title | Immunology letters |
| container_volume | 184 |
| creator | Lee, Seung Hoon Jhun, JooYeon Byun, Jae-Kyung Kim, Eun-Kyung Jung, KyoungAh Lee, Ji Eun Choi, Jong Young Park, Sung-Hwan Cho, Mi-La |
| description | Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells. |
| doi_str_mv | 10.1016/j.imlet.2017.02.004 |
| format | article |
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Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-98b2a1d678fc526062dc2ce9704c334c560b06620bde5c080de33f676beed1293</citedby><cites>FETCH-LOGICAL-c480t-98b2a1d678fc526062dc2ce9704c334c560b06620bde5c080de33f676beed1293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28237848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Seung Hoon</creatorcontrib><creatorcontrib>Jhun, JooYeon</creatorcontrib><creatorcontrib>Byun, Jae-Kyung</creatorcontrib><creatorcontrib>Kim, Eun-Kyung</creatorcontrib><creatorcontrib>Jung, KyoungAh</creatorcontrib><creatorcontrib>Lee, Ji Eun</creatorcontrib><creatorcontrib>Choi, Jong Young</creatorcontrib><creatorcontrib>Park, Sung-Hwan</creatorcontrib><creatorcontrib>Cho, Mi-La</creatorcontrib><title>IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - metabolism</subject><subject>Adipogenesis</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Cell Differentiation</subject><subject>Cell Line</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Fatty Liver - genetics</subject><subject>Fatty Liver - immunology</subject><subject>Fatty Liver - metabolism</subject><subject>Fatty Liver - pathology</subject><subject>Gene Expression</subject><subject>I-kappa B Kinase - metabolism</subject><subject>IL-17</subject><subject>Immunomodulation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inflammation Mediators</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - metabolism</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Obesity - immunology</subject><subject>Obesity - metabolism</subject><subject>Obesity - pathology</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Signal Transduction</subject><subject>TBK1</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAURi1ERaeFX4CEvGSTcP2I41mARKs-RjMSC4rEznKcG-ohiQc7U5h_j8OULtiwupvz3ce5hLxmUDJg6t229EOPU8mB1SXwEkA-Iwum62UBleTPySJTVcFlrU_JWUpbAFYJKV6QU665qLXUC2JWm4LV1P7yiVrnsMdoJ0x0ukfqx663w2CnEA90F8O3iCn5MNLQ0dBgmgk6eIf0wVt6d7Fm1I4tXa0v1ld0Z6f7n_bwkpx0tk_46rGeky_XV3eXt8Xm083q8uOmcFLDVCx1wy1rVa07V3EFireOO1zWIJ0Q0lUKGlCKQ9Ni5UBDi0J0qlYNYsv4UpyTt8e-ec8fe0yTGXzK5_R2xLBPJmvhleYgq4yKI-piSCliZ3bRDzYeDAMzmzVb88esmc0a4Cabzak3jwP2zYDtU-avygy8PwKYz3zwGE1yHkeHrY_oJtMG_58BH_7Ju96P3tn-Ox4wbcM-jtmgYSblgPk8P3f-LVMCBGNfxW-KI54g</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Lee, Seung Hoon</creator><creator>Jhun, JooYeon</creator><creator>Byun, Jae-Kyung</creator><creator>Kim, Eun-Kyung</creator><creator>Jung, KyoungAh</creator><creator>Lee, Ji Eun</creator><creator>Choi, Jong Young</creator><creator>Park, Sung-Hwan</creator><creator>Cho, Mi-La</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway</title><author>Lee, Seung Hoon ; Jhun, JooYeon ; Byun, Jae-Kyung ; Kim, Eun-Kyung ; Jung, KyoungAh ; Lee, Ji Eun ; Choi, Jong Young ; Park, Sung-Hwan ; Cho, Mi-La</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-98b2a1d678fc526062dc2ce9704c334c560b06620bde5c080de33f676beed1293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes - cytology</topic><topic>Adipocytes - metabolism</topic><topic>Adipogenesis</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Cell Differentiation</topic><topic>Cell Line</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Fatty Liver - genetics</topic><topic>Fatty Liver - immunology</topic><topic>Fatty Liver - metabolism</topic><topic>Fatty Liver - pathology</topic><topic>Gene Expression</topic><topic>I-kappa B Kinase - metabolism</topic><topic>IL-17</topic><topic>Immunomodulation</topic><topic>Inflammation - immunology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Inflammation Mediators</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - metabolism</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Obesity - immunology</topic><topic>Obesity - metabolism</topic><topic>Obesity - pathology</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Signal Transduction</topic><topic>TBK1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Seung Hoon</creatorcontrib><creatorcontrib>Jhun, JooYeon</creatorcontrib><creatorcontrib>Byun, Jae-Kyung</creatorcontrib><creatorcontrib>Kim, Eun-Kyung</creatorcontrib><creatorcontrib>Jung, KyoungAh</creatorcontrib><creatorcontrib>Lee, Ji Eun</creatorcontrib><creatorcontrib>Choi, Jong Young</creatorcontrib><creatorcontrib>Park, Sung-Hwan</creatorcontrib><creatorcontrib>Cho, Mi-La</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Seung Hoon</au><au>Jhun, JooYeon</au><au>Byun, Jae-Kyung</au><au>Kim, Eun-Kyung</au><au>Jung, KyoungAh</au><au>Lee, Ji Eun</au><au>Choi, Jong Young</au><au>Park, Sung-Hwan</au><au>Cho, Mi-La</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>184</volume><spage>67</spage><epage>75</epage><pages>67-75</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>Highlights • IL-17 induced TBK1-mediates immune inflammatory response in adipocytes and downregulated adipocyte differentiation. • Loss of IL-17 reduced inflammation and improved fatty liver in obesity animal model. • The inhibition of TBK1 could decrease inflammatory response in RAW 264.7 cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28237848</pmid><doi>10.1016/j.imlet.2017.02.004</doi><tpages>9</tpages></addata></record> |
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| ispartof | Immunology letters, 2017-04, Vol.184, p.67-75 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | Elsevier |
| subjects | Adipocytes - cytology Adipocytes - metabolism Adipogenesis Allergy and Immunology Animals Biomarkers Cell Differentiation Cell Line Cytokines - genetics Cytokines - metabolism Disease Models, Animal Fatty Liver - genetics Fatty Liver - immunology Fatty Liver - metabolism Fatty Liver - pathology Gene Expression I-kappa B Kinase - metabolism IL-17 Immunomodulation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Inflammation Mediators Interleukin-17 - genetics Interleukin-17 - metabolism Macrophages - immunology Macrophages - metabolism Male Mice Mice, Knockout Obesity Obesity - genetics Obesity - immunology Obesity - metabolism Obesity - pathology Protein-Serine-Threonine Kinases - metabolism Signal Transduction TBK1 |
| title | IL-17 axis accelerates the inflammatory progression of obese in mice via TBK1 and IKBKE pathway |
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