Effects of Afobazole on Postnatal Development of Rat Offspring

Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-02, Vol.162 (4), p.441-444
Main Authors: Bugaeva, L. I., Denisova, T. D., Sergeeva, S. A., Morozova, Yu. A., Kharlamov, I. V.
Format: Article
Language:English
Subjects:
Animal behavior
Animals
Animals, Newborn
Anti-Anxiety Agents - adverse effects
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Benzimidazoles - adverse effects
Biomedical and Life Sciences
Biomedicine
Body weight
Body weight gain
Cell Biology
Eye
Female
Internal Medicine
Laboratory Medicine
Learning
Maternal Exposure - adverse effects
Maze Learning - drug effects
Memory
Memory - drug effects
Morpholines - adverse effects
Motor Activity - drug effects
Motor task performance
Muscle Strength - drug effects
Muscle, Skeletal - drug effects
Muscle, Skeletal - growth & development
Pathology
Pharmacology and Toxicology
Pregnancy
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - physiopathology
Rats
Reflex, Pupillary - drug effects
Reflexes
Rodents
Sexual Maturation - drug effects
Vagina
Weight Gain - drug effects
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Summary:Physical development, development of sensory and motor reflexes, behavioral and mnestic patterns were studied infantile and juvenile rat pups born by female rats receiving Afobazole during pregnancy. Physical development and development of sensory and motor reflexes in rats were completed without pathologies by the age of 2 months. During the infantile period, the rat pups demonstrated reduced body weight gain, delayed eye opening and pupillary response formation, decreased muscle force, and suppressed motor behavior. During the juvenile period, body weight gain and development of motor behavior were intensified. Females demonstrated later vagina opening and poorer mnestic responses. In males, the terms of sexual maturation were unchanged and processes of learning and memory retrieval were not impaired.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3635-z