Microbial cell preparation in enteral feeding in critically ill patients: A randomized, double-blind, placebo-controlled clinical trial

Abstract Gut failure is a common condition in critically ill patients in the intensive care unit (ICU). Enteral feeding is usually the first line of choice for nutrition support in critically ill patients. However, enteral feeding has its own set of complications such as alterations in gut transit t...

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Bibliographic Details
Published in:Journal of critical care 2016-04, Vol.32, p.182-188
Main Authors: Malik, Ausama A, Rajandram, Retnagowri, Tah, Pei Chien, Hakumat-Rai, Vineya-Rai, Chin, Kin-Fah
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Adult
Aged
C-Reactive Protein - analysis
Cancer
Cancer therapies
Clinical outcome
Critical Care
Critical Illness - therapy
Critically ill
Double-Blind Method
Ecosystems
Enteral feeding
Enteral Nutrition - methods
Female
Gastrointestinal Diseases - therapy
Gut function
Heart attacks
Humans
Intensive Care Units - statistics & numerical data
Length of Stay - statistics & numerical data
Leukocyte Count
Male
Microbial cell preparation
Middle Aged
Motility
Patients
Probiotics
Probiotics - administration & dosage
Respiration, Artificial - statistics & numerical data
Sepsis
Time Factors
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Summary:Abstract Gut failure is a common condition in critically ill patients in the intensive care unit (ICU). Enteral feeding is usually the first line of choice for nutrition support in critically ill patients. However, enteral feeding has its own set of complications such as alterations in gut transit time and composition of gut eco-culture. The primary aim of this study was to investigate the effect of microbial cell preparation on the return of gut function, white blood cell count, C-reactive protein levels, number of days on mechanical ventilation, and length of stay in ICU. A consecutive cohort of 60 patients admitted to the ICU in University Malaya Medical Centre requiring enteral feeding were prospectively randomized to receive either treatment (n = 30) or placebo (n = 30). Patients receiving enteral feeding supplemented with a course of treatment achieved a faster return of gut function and required shorter duration of mechanical ventilation and shorter length of stay in the ICU. However, inflammatory markers did not show any significant change in the pretreatment and posttreatment groups. Overall, it can be concluded that microbial cell preparation enhances gut function and the overall clinical outcome of critically ill patients receiving enteral feeding in the ICU.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2015.12.008