Synthesis of 2‑Pyridyl-benzimidazole Iridium(III), Ruthenium(II), and Platinum(II) Complexes. Study of the Activity as Inhibitors of Amyloid‑β Aggregation and Neurotoxicity Evaluation

• Published in: Inorganic chemistry 2015-01, Vol.54 (2), p.470-475
• Main Authors: Yellol, Gorakh S, Yellol, Jyoti G, Kenche, Vijaya B, Liu, Xiang Ming, Barnham, Kevin J, Donaire, Antonio, Janiak, Christoph, Ruiz, José
• Format: Article
• Language: English
• Subjects: Agglomeration; Amyloid beta-Peptides - chemistry; Amyloid beta-Peptides - toxicity; Animals; Benzimidazoles - chemistry; Cationic; Chemistry Techniques, Synthetic; Design analysis; Diffraction; Drug Design; Female; Fluorescence; Iridium - chemistry; Ligands; Mice; Models, Molecular; Molecular Conformation; Neurons - cytology; Neurons - drug effects; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Peptide Fragments - chemistry; Peptide Fragments - toxicity; Platinum - chemistry; Pregnancy; Protein Multimerization - drug effects; Protein Structure, Secondary; Ruthenium - chemistry; Synthesis; Toxicity; Unit cell
• ISSN: 0020-1669; 1520-510X
• DOI: 10.1021/ic502119b

The design of small molecules that can target the aggregation of Aβ as potential therapeutic agents for Alzheimer’s disease is an area of study that has attracted a lot of attention recently. The novel ligand methyl 1-butyl-2-pyridyl-benzimidazole carboxylate was prepared for the synthesis of a series of new iridium(III), ruthenium(II), and platinum(II) 2-pyridyl-benzimidazole complexes. The crystal structure of the half-sandwich iridium(III) complex was established by X-ray diffraction. An arrangement of two cationic complexes in the unit cell is observed, and it seems to be organized by weak π···π interactions that are taking place between two symmetry-related benzimidazole ring systems. All new compounds inhibited aggregation of Aβ1–42 in vitro as shown by both thioflavin T fluorescence assay and transmission electron microscopy. Among them the Ir compound rescued the toxicity of Aβ1–42 in primary cortical neurons effectively.