In vitro toxicity, apoptosis and antimicrobial effects of phyto-mediated copper oxide nanoparticles

Herein, copper oxide nanoparticles (CuONPs) are proposed for widespread use in emerging biomedical applications. The aim of this study is to synthesize and characterize CuONPs using the aqueous dried fruit extract of Tribulus terrestris and assess their potential in vitro cytotoxicity and antibacter...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (112), p.110986-110995
Main Authors: Gopinath, V, Priyadarshini, S, Al-Maleki, A R, Alagiri, M, Yahya, Rosiyah, Saravanan, S, Vadivelu, Jamuna
Format: Article
Language:English
Subjects:
Anticancer properties
Antiinfectives and antibacterials
Biocompatibility
Copper oxides
In vitro testing
Nanoparticles
Synthesis
Toxicity
Tribulus terrestris
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Summary:Herein, copper oxide nanoparticles (CuONPs) are proposed for widespread use in emerging biomedical applications. The aim of this study is to synthesize and characterize CuONPs using the aqueous dried fruit extract of Tribulus terrestris and assess their potential in vitro cytotoxicity and antibacterial activity. The CuONPs bio-physical and morphological properties are characterized via different analytical techniques. The synthesized particles are highly stable and spherical with particle sizes in the range of 5-22 nm. Confocal microscopy reveals that ROS generation is the potent mechanism behind the role of CuONPs mediated antimicrobial toxicity. In addition, MTT and apoptotic analyses illustrate that the CuONPs are relatively cytofriendly toward human mesenchymal stem cells and also exhibit anti-cancer activity on human adenocarcinoma AGS cell lines. These results clearly indicate that the prepared copper oxide nanoparticles are safe and their application can be expanded as effectual antimicrobial and anticancer agents for pharmaceutical applications.
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra13871c