A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

The synthesis and properties of 2,7-diamino-1,4,8-triazanaphthalene (azaDANP) are described. AzaDANP is protonated only at a weakly acidic pH to bind to the cytosine bulge DNA duplex selectively. Upon binding of azaDANP to the cytosine bulge DNA, a new absorption band at 407 nm appears, and the abso...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-02, Vol.15 (6), p.1313-1316
Main Authors: Aikawa, H, Yano, A, Nakatani, K
Format: Article
Language:English
Subjects:
Binding Sites
Cytosine - chemistry
DNA - chemistry
Hydrogen-Ion Concentration
Molecular Structure
Naphthalenes - chemical synthesis
Naphthalenes - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and properties of 2,7-diamino-1,4,8-triazanaphthalene (azaDANP) are described. AzaDANP is protonated only at a weakly acidic pH to bind to the cytosine bulge DNA duplex selectively. Upon binding of azaDANP to the cytosine bulge DNA, a new absorption band at 407 nm appears, and the absorption change of azaDANP on binding to the target is very sensitive to environmental pH with a bell-shaped pH-absorption profile.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob02273a