Examination of the correlation between the manual and automated serological testing methods for syphilis

We evaluated the correlation between the conventional manual serological testing method for syphilis and a novel automated serological testing method and between six different reagents used in the automated method. Twenty‐six serum samples, which were positive on non‐treponemal manual serological te...

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Bibliographic Details
Published in:Journal of dermatology 2012-04, Vol.39 (4), p.355-361
Main Authors: ONOE, Tomohiko, HONDA, Mariko, MATSUO, Koma, SASAKI, Hajime, SAWAMURA, Masayuki, ONOE, Yasuhiko, IWAMOTO, Aikichi, ONODERA, Shoichi, KAWANA, Takashi, TADA, Yuki, NIMURA, Michihito, NAKAGAWA, Hidemi
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Bacterial - blood
Automation
Humans
Indicators and Reagents
Japan
Regression Analysis
Serological tests
sexually transmitted disease
Statistical analysis
Syphilis
Syphilis - diagnosis
Syphilis - immunology
syphilis serodiagnosis
Syphilis Serodiagnosis - methods
Syphilis Serodiagnosis - statistics & numerical data
Treponema pallidum
Treponema pallidum - immunology
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Summary:We evaluated the correlation between the conventional manual serological testing method for syphilis and a novel automated serological testing method and between six different reagents used in the automated method. Twenty‐six serum samples, which were positive on non‐treponemal manual serological testing, were obtained from 19 patients with early syphilis. The samples were manually analyzed using the non‐treponemal serological test for syphilis kit and automatically analyzed using six different reagents approved by the Ministry of Health, Labor and Welfare in Japan. Statistically significant correlations were observed between most of the reagents used in the automated testing (r = 0.652–0.996, P 
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2011.01341.x