Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy

Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum rat...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-02, Vol.15 (7), p.1565-1569
Main Authors: Ueda, Masafumi, Ashizawa, Kengo, Sugikawa, Kouta, Koumoto, Kazuya, Nagasaki, Takeshi, Ikeda, Atsushi
Format: Article
Language:English
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Summary:Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.
ISSN:1477-0520
1477-0539
DOI:10.1039/c6ob02142e