Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy

Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum rat...

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Published in:Organic & biomolecular chemistry 2017-02, Vol.15 (7), p.1565-1569
Main Authors: Ueda, Masafumi, Ashizawa, Kengo, Sugikawa, Kouta, Koumoto, Kazuya, Nagasaki, Takeshi, Ikeda, Atsushi
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cited_by cdi_FETCH-LOGICAL-c422t-772a0f79f9d6de82572704d432ca52117b887b6e2e432181d60bfc3685afe3fb3
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container_issue 7
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container_title Organic & biomolecular chemistry
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creator Ueda, Masafumi
Ashizawa, Kengo
Sugikawa, Kouta
Koumoto, Kazuya
Nagasaki, Takeshi
Ikeda, Atsushi
description Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.
doi_str_mv 10.1039/c6ob02142e
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title Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy
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