Comparative sensitivity of cholinesterases in vertebrates and invertebrates to highly specific organophosphorus inhibitors, diisopropyl fluorophosphate (DFP) and (2-ethoxymethyl phosphoryl thioethyl) ethyl (methyl) sulphonium sulphomethylate (GD-42)

The review presents the data on a comparative reactivity of 68 cholinesterase preparations from various organs and tissues in a number of vertebrates and invertebrates based on the sensitivity to the two highly specific and most studied organophosphorus inhibitors, diisopropyl fluorophosphates (DFP)...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2015-11, Vol.51 (6), p.471-479
Main Authors: Basova, N. E., Kormilitsyn, B. N., Perchenok, A. Yu, Rozengart, E. V., Saakov, V. S., Suvorov, A. A.
Format: Article
Language:English
Subjects:
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Comparative and Ontogenic Biochemistry
Comparative studies
Enzymes
Evolutionary Biology
Invertebrates
Life Sciences
Vertebrates
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Summary:The review presents the data on a comparative reactivity of 68 cholinesterase preparations from various organs and tissues in a number of vertebrates and invertebrates based on the sensitivity to the two highly specific and most studied organophosphorus inhibitors, diisopropyl fluorophosphates (DFP) and (2-ethoxymethyl phosphoryl thioethyl) ethyl (methyl) sulphonium sulphomethylate (GD-42). An analysis of the data obtained suggests a great diversity of enzymologic characteristics of cholinesterase preparations in vertebrates and invertebrates observed even in closely related enzymes in animals at virtually the same level of evolutionary development.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093015060034