Dynamic changes of the intraocular pressure and the pressure of cerebrospinal fluid in nonglaucomatous neurological patients

• Published in: Acta ophthalmologica (Oxford, England) England), 2017-03, Vol.95 (2), p.e138-e143
• Main Authors: González‐Camarena, Pedro Iván, San‐Juan, Daniel, González‐Olhovich, Irene, Rodríguez‐Arévalo, David, Lozano‐Elizondo, David, Trenado, Carlos, Anschel, David J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Case-Control Studies; cerebrospinal fluid pressure; Female; Follow-Up Studies; Humans; Intracranial Hypertension - physiopathology; intracranial pressure; Intracranial Pressure - physiology; intraocular pressure; Intraocular Pressure - physiology; Male; Middle Aged; Ophthalmology; Prospective Studies; Time Factors; translaminar pressure difference; Young Adult
• ISSN: 1755-375X; 1755-3768
• DOI: 10.1111/aos.13236

Purpose To describe the dynamic changes of the intraocular pressure (IOP) and intracranial pressure (ICP) with normal or pathological values (intracranial hypertension) in nonglaucomatous neurological patients during lumbar punction (LP). Methods Case–control study, prospective measurement of tonometry in both groups referred for LP. Intraocular pressure, ICP and translaminar pressure difference (TPD) were compared pre‐ and post‐LP. Results Thirty‐six patients (72 eyes) with mean age of 38.5 (16–64) years and BMI of 26.81 kg/m2 were analysed. The initial mean ICP was 12.81 (± 6.6) mmHg. The mean TPD before and after the LP was 1.48 mmHg and 0.65 mmHg, respectively. The mean IOP of both eyes decreased to 0.8 mmHg post‐LP in patients with pathological ICP (p = 0.0193) and normal ICP (p = 0.006). Conclusions We found a statistically significant decrease of the IOP post‐LP compared to the pre‐LP in both groups, being higher in patients with pathological ICP. There were no significant differences of the IOP in patients with normal versus pathological ICP pre‐LP/post‐LP; neither was found a correlation between ICP and IOP.