Histopathologic features in actinic cheilitis by the comparison of grading dysplasia systems

Objective This study aimed to determine the histopathologic findings in actinic cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from AC to LSCC based on the comparison of two dysplasia classificatio...

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Bibliographic Details
Published in:Oral diseases 2017-03, Vol.23 (2), p.219-224
Main Authors: Pilati, SFM, Bianco, BC, Vieira, DSC, Modolo, F
Format: Article
Language:English
Subjects:
actinic cheilitis
binary
Carcinoma, Squamous Cell - pathology
Cell Nucleolus - pathology
Cell Nucleus - pathology
Cell Transformation, Neoplastic
Cheilitis - classification
Cheilitis - pathology
Classification
Dentistry
epithelial dysplasia
Histopathology
Humans
Lip Neoplasms - pathology
Mitotic Index
Neoplasm Staging
Oral cancer
squamous cell carcinoma
World Health Organization
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Summary:Objective This study aimed to determine the histopathologic findings in actinic cheilitis (AC) and lip squamous cell carcinomas (LSCC) diagnosed at Federal University of Santa Catarina in order to attempt to predict the evolution from AC to LSCC based on the comparison of two dysplasia classification systems. Methods Histopathologic features were evaluated according to the World Health Organization classification of dysplasia and binary system of classification. Also, in LSCC, pattern, stage of invasion, and degree of keratinization were evaluated. A total of 58 cases of AC and 70 cases of LSCC were studied, and data correlation was performed using statistical analysis. Results The presence of dyskeratosis and keratin pearls was found to be strongly associated with severe dysplasia and could represent higher proximity between the severe dysplasia in AC and LSCC. Also, changes related to the nuclei, such as hyperchromasia, nuclear pleomorphism, anisonucleosis, increase in the number and size of nucleoli, increased number of mitoses, and atypical mitoses, indicate progression in dysplasia spectrum. Conclusion Knowledge of clinical and histological features of AC and LSCC leads to better understanding of factors possibly associated with malignant transformation of epithelial dysplasia.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12597