Prognostic value of age in neurological cancer: an analysis of 22,393 cases from the SEER database

Although the risk of neurological cancer (NC) is age-dependent, few studies have evaluated the prognostic value of age in determining NC survival in a large population. The aim of this retrospective study was to compare the long-term survival of young and elderly NC patients. We searched the Surveil...

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Bibliographic Details
Published in:Tumor biology 2015-11, Vol.36 (11), p.8341-8348
Main Authors: Tian, Minjie, Zhu, Donglin, Chen, Daowen, Huo, Xiaoli, Ge, Jianqing, Lu, Jie, Zhang, Li, Shi, Jingping
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Brain cancer
Cancer Research
Case studies
Female
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Middle Aged
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - pathology
Nervous System Diseases - diagnosis
Nervous System Diseases - epidemiology
Nervous System Diseases - pathology
Prognosis
Research Article
Risk Factors
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Summary:Although the risk of neurological cancer (NC) is age-dependent, few studies have evaluated the prognostic value of age in determining NC survival in a large population. The aim of this retrospective study was to compare the long-term survival of young and elderly NC patients. We searched the Surveillance, Epidemiology, and End-Results database and identified 22,393 patients who were diagnosed with NC between 1988 and 2003 and were treated with surgery. Patients were categorized as young (≤40 years old) or elderly (>40 years old), and 5-year NC-specific survival (NCSS) data were obtained for each patient. A Kaplan-Meier survival analysis and the Cox proportional hazards model were used to analyze long-term survival outcomes and risk factors. The two groups differed significantly in terms of pathological grade, histological type, stage, and tumor size ( P  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-3599-4