An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial

Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in symptomatic nondiabetic patients in the PROMISE trial. The outcomes we...

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Bibliographic Details
Published in:The American heart journal 2017-02, Vol.184, p.133-140
Main Authors: Voora, Deepak, Coles, Adrian, Lee, Kerry L., Hoffmann, Udo, Wingrove, James A., Rhees, Brian, Huang, Lin, Daniels, Susan E., Monane, Mark, Rosenberg, Steven, Shah, Svati H., Kraus, William E., Ginsburg, Geoffrey S., Douglas, Pamela S.
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Age Factors
Aged
Angina pectoris
Blood pressure
Cardiovascular disease
Clinical outcomes
Computed Tomography Angiography
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - genetics
Coronary Artery Disease - surgery
Coronary vessels
Diagnostic tests
Family medical history
Female
Gene expression
Heart attacks
Hispanic Americans
Humans
Hypotheses
Laboratories
Male
Medical imaging
Middle Aged
Myocardial Revascularization - statistics & numerical data
Odds Ratio
Patients
Proportional Hazards Models
Prospective Studies
Real-Time Polymerase Chain Reaction
Risk Assessment
RNA, Messenger - metabolism
Sex Factors
Studies
Transcriptome - genetics
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Summary:Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in symptomatic nondiabetic patients in the PROMISE trial. The outcomes were oCAD (≥70% stenosis in ≥1 vessel or ≥50% left main stenosis on CT angiography [CTA]) and a composite endpoint of death, myocardial infarction, revascularization, or unstable angina. The ASGES was determined in 2370 nondiabetic participants (47.5% male, median age 59.5 years, median follow-up 25 months), including 1137 with CTA data. An ASGES >15 was associated with oCAD (odds ratio 2.5 [95% CI 1.6-3.8], P
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2016.11.004