Neutrophil Extracellular Traps in Atherosclerosis and Atherothrombosis

Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functiona...

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Bibliographic Details
Published in:Circulation research 2017-02, Vol.120 (4), p.736-743
Main Authors: Döring, Yvonne, Soehnlein, Oliver, Weber, Christian
Format: Article
Language:English
Subjects:
Animals
Antigen-presenting cells
Arteriosclerosis
Atherogenesis
Atherosclerosis
Atherosclerosis - metabolism
Atherosclerosis - pathology
Cell activation
Chromatin
Endothelial cells
Extracellular Traps - metabolism
Humans
Immune response
Inflammation
Leukocytes (neutrophilic)
Neutrophils
Neutrophils - metabolism
Neutrophils - pathology
Plaques
T cell receptors
Thrombosis
Thrombosis - metabolism
Thrombosis - pathology
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Summary:Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.116.309692