Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-02, Vol.162 (4), p.462-465
Main Authors: Drozd, N. N., Logvinova, Yu. S., Torlopov, M. A., Udoratina, E. V.
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - pharmacology
Anticoagulants
Anticoagulants - chemistry
Anticoagulants - pharmacology
Antithrombin
Antithrombin III - antagonists & inhibitors
Antithrombin III - metabolism
Biomedical and Life Sciences
Biomedicine
Blood coagulation
Blood Coagulation - drug effects
Blood Coagulation Tests
Blood Platelets - drug effects
Cell Biology
Coagulation
Dextran
Dextran sulfate
Dextran Sulfate - pharmacology
Dextrans
Dextrans - chemistry
Dextrans - pharmacology
Heparin - pharmacology
Humans
Internal Medicine
Laboratory Medicine
Molecular Weight
Pathology
Platelet aggregation
Platelet Aggregation - drug effects
Serine
Structure-Activity Relationship
Sulfates
Thrombin
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Summary:Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3640-2