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Activities of ectonucleotidases and adenosine deaminase in platelets of cattle experimentally infected by Fasciola hepatica

The enzymatic activities of NTPDase, 5′-nucleotidase and adenosine deaminase (ADA) are important in regulating the concentration of adenine nucleotides, molecules known to be involved on platelet aggregation. Fasciolosis causes coagulation disorders that have not been completely elucidated. Taking i...

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Published in:Experimental parasitology 2017-05, Vol.176, p.16-20
Main Authors: Fracasso, Mateus, Da Silva, Aleksandro S., Baldissera, Matheus D., Bottari, Nathieli B., Gabriel, Mateus E., Piva, Manoela M., Stedille, Fernanda A., Christ, Ricardo, Rhoden, Leandro A., Henker, Luan C., Moresch, Vera M., Schetinger, Maria Rosa C., Mendes, Ricardo E.
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Language:English
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Summary:The enzymatic activities of NTPDase, 5′-nucleotidase and adenosine deaminase (ADA) are important in regulating the concentration of adenine nucleotides, molecules known to be involved on platelet aggregation. Fasciolosis causes coagulation disorders that have not been completely elucidated. Taking into consideration the association between the purinergic system and hemostasis, this study aimed to evaluate the enzymatic activities of NTPDase (hydrolyze ATP and ADP), 5′-nucleotidase (hydrolyze AMP) and ADA (deamination of adenosine) in platelets from cattle experimentally infected by Fasciola hepatica on days 20, 40, 60 and 80 post-infection (PI). For this study, 10 healthy Friesian steers were separated into two groups: the group A (n = 5) was used as uninfected control, and the group B was composed of steers experimentally infected by F. hepatica (n = 5). The number of platelets did not differ between groups in the periods evaluated. Reduction of NTPDase (p 
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2017.02.014