Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics

• Published in: Biological & pharmaceutical bulletin 2017/03/01, Vol.40(3), pp.243-248
• Main Authors: Higashisaka, Kazuma, Nagano, Kazuya, Yoshioka, Yasuo, Tsutsumi, Yasuo
• Format: Article
• Language: English
• Subjects: Animals; Environmental Exposure - adverse effects; Female; hazard; Humans; kinetics; Male; nanoparticle; Nanoparticles - adverse effects; Nanoparticles - chemistry; Nanotechnology; Particulate Matter - adverse effects; Particulate Matter - chemistry; Pharmacokinetics; physical property; Pregnancy; real-world exposure
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.b16-00854

In the past decade, nanotechnology has advanced rapidly, and many products containing nanoparticles are now an important part of our daily lives. Despite our increasing exposure to nanoparticles, however, information regarding the absorption, distribution, metabolism, excretion, and toxicity of nanoparticles remains limited. In this review, we introduce our group’s ongoing research into the biological effects and toxicities of nanoparticles, which we broadly refer to as “nano-safety research.” In addition to determining the biological effects of nanoparticles and elucidating the underlying mechanisms of those effects, we are also exploring the associations among the physicochemical properties and kinetics of nanoparticles. Furthermore, we are currently developing a battery of biomarkers that we hope will be used to predict the biological effects of nanoparticles during the early stages of development. Our research provides valuable basic information on the safety of nanoparticles. We hope that this information will be used for the development of better assessments of nanoparticles safety and for the creation of more appropriate regulations to ensure not only the safety but also the sustainability of nanotechnology.