Cytologic findings of mammary analogue secretory carcinoma arising in the thyroid

Mammary analogue secretory carcinoma (MASC) of the salivary gland, first described by Skálová et al in 2010, is a tumor that morphologically and genetically resembles breast secretory carcinoma harboring ETV6‐NTRK3 fusion gene. To date, only seven cases of primary thyroid MASC have been described. T...

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Bibliographic Details
Published in:Diagnostic cytopathology 2017-06, Vol.45 (6), p.552-556
Main Authors: Rodríguez‐Urrego, Paula A., Dogan, Snjezana, Lin, Oscar
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Breast cancer
cytology
Humans
Male
Mammary Analogue Secretory Carcinoma - genetics
Mammary Analogue Secretory Carcinoma - pathology
MASC
Middle Aged
Oncogene Proteins, Fusion - genetics
thyroid
Thyroid cancer
Thyroid gland
Thyroid Gland - pathology
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
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Description
Summary:Mammary analogue secretory carcinoma (MASC) of the salivary gland, first described by Skálová et al in 2010, is a tumor that morphologically and genetically resembles breast secretory carcinoma harboring ETV6‐NTRK3 fusion gene. To date, only seven cases of primary thyroid MASC have been described. The overall findings are similar to those seen in the salivary gland counterpart including the ETV6‐NTRK3 fusion gene. This is the second report describing the cytologic features of MASC at this primary location, which also showed a classical type papillary carcinoma component. Diagn. Cytopathol. 2017;45:552–556. © 2017 Wiley Periodicals, Inc.
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23692