Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer

Highlights • Novel tumour-specific multimodal imaging agent that will aid in surgical procedures. • Recognizing both neoplastic as well as tumour surrounding stromal cells. • Antibody-based, providing large imaging windows and high specific signals. • One administration sufficient for pre-, intra- a...

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Bibliographic Details
Published in:Oral oncology 2017-03, Vol.66, p.1-8
Main Authors: Boonstra, M.C, Van Driel, P.B.A.A, Keereweer, S, Prevoo, H.A.J.M, Stammes, M.A, Baart, V.M, Löwik, C.W.G.M, Mazar, A.P, van de Velde, C.J.H, Vahrmeijer, A.L, Sier, C.F.M
Format: Article
Language:English
Subjects:
Fluorescence
Head and neck
Hematology, Oncology and Palliative Medicine
Hybrid
Imaging
Intraoperative
Near-infrared
Oral cancer
Otolaryngology
Real-time
SPECT
Surgery
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Description
Summary:Highlights • Novel tumour-specific multimodal imaging agent that will aid in surgical procedures. • Recognizing both neoplastic as well as tumour surrounding stromal cells. • Antibody-based, providing large imaging windows and high specific signals. • One administration sufficient for pre-, intra- and postoperative imaging. • The agent can be applied in low doses and visualizes millimetre sized metastases.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2016.12.026