Pre‐implantation genetic screening among women experiencing recurrent failure of in vitro fertilization

• Published in: International journal of gynecology and obstetrics 2017-06, Vol.137 (3), p.314-318
• Main Authors: Hatirnaz, Safak, Ozer, Alev, Hatirnaz, Ebru, Atasever, Melahat, Başaranoglu, Serdar, Kanat‐Pektas, Mine, Api, Murat
• Format: Article
• Language: English
• Subjects: Adult; Chromosome Aberrations; Female; Fertilization in Vitro; Fluorescent in situ hybridization; Genetic screening; Humans; Intracytoplasmic sperm injection; Pregnancy; Preimplantation Diagnosis; Pre‐implantation; Recurrence; Recurrent in vitro fertilization failure; Retrospective Studies; Sperm Injections, Intracytoplasmic; Treatment Failure
• ISSN: 0020-7292; 1879-3479
• DOI: 10.1002/ijgo.12135

Objective To determine the efficiency of pre‐implantation genetic screening (PGS) among women scheduled to undergo intracytoplasmic sperm injection who had experienced recurrent in vitro fertilization (IVF) failure. Methods The present retrospective cohort study reviewed the medical records of consecutive women who had experienced recurrent IVF failure and had presented at a private IVF facility in Trabzon Province, Turkey, to undergo intracytoplasmic sperm injection between May 1, 2012, and December 31, 2014. Patient data and perinatal outcomes were compared between patients who underwent PGS and those who did not. Results There were 88 patients included in the study; 43 patients had undergone PGS and 45 had declined to do so. No differences were detected in the clinical pregnancy rate (P=0.846), spontaneous abortion rate (P=0.416), number of perinatal deaths (P=0.162), or the number of live deliveries (P=0.188) between the groups of patients. The pregnancies included in the study resulted in 25 neonates being delivered; 24 had normal karyotypes, and one neonate from the control group had a karyotype of 46, XX, 9ph. Among the 19 embryos that were not transferred, the most frequently encountered chromosomal anomalies were diploidy, monosomy X, and 2N/N/4N mosaicism, detected in 7 (37%), 2 (11%), and 2 (11%) embryos, respectively. Conclusion PGS had no effect on perinatal outcomes among women experiencing recurrent IVF failure. The addition of pre‐implantation genetic screening to intracytoplasmic sperm injection did not improve perinatal outcomes among women experiencing recurrent in vitro fertilization failure.