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Current Insights in the Placebo and Nocebo Phenomena
[...]a nocebo response can occur with an inert or noninert substance as a worsening of the diagnosed condition or as treatment-emergent adverse effects. [...]when indication-appropriate active treatment is administered, the therapeutic effect may be a combination of the pharmacologic activity of the...
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Published in: | Clinical therapeutics 2017-03, Vol.39 (3), p.456-457 |
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Main Author: | |
Format: | Article |
Language: | English |
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Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [...]a nocebo response can occur with an inert or noninert substance as a worsening of the diagnosed condition or as treatment-emergent adverse effects. [...]when indication-appropriate active treatment is administered, the therapeutic effect may be a combination of the pharmacologic activity of the treating agent and a placebo effect, as demonstrated in an experiment of open and hidden analgesic administration using an infusion pump where pain relief was significantly reduced when the patients were unaware that an analgesic was being administered.2 It is also common usage to refer to all improvement in a placebo arm of a randomized clinical trial (RCT) as a placebo response and all worsening and adverse events as a nocebo response, even though fluctuation of symptoms occurs with the natural progression of many illnesses. [...]the terms placebo and nocebo are used differently by different authors or even by the same authors when reporting different studies. References 1 F.G. Miller, T.J. Kaptchuk, The power of context: reconceptualizing the placebo effect, J R Soc Med, Vol. 101, 2008, 222-225 2 L. Colloca, L. Lopiano, M. Lanotte, F. Benedetti, Overt versus covert treatment for pain, anxiety, and Parkinson’s disease, Lancet Neurol, Vol. 3, 2004, 679-684 3 K. Weimer, B. Horing,... |
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ISSN: | 0149-2918 1879-114X |
DOI: | 10.1016/j.clinthera.2017.02.002 |