Prognostic significance of CD133 and ezrin expression in colorectal carcinoma

Despite the improvement in the diagnostic and the therapeutic modalities, colorectal cancer (CRC) morbidity and mortality remain high in both the developed and the developing countries. So, we are in a need to recognize new efficient diagnostic and prognostic biomarkers of CRC. That may help in prov...

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Bibliographic Details
Published in:IUBMB life 2017-05, Vol.69 (5), p.328-340
Main Authors: Fathi, Anan, Mosaad, Hala, Hussein, Samia, Roshdy, Mona, Ismail, Eman I.
Format: Article
Language:English
Subjects:
AC133 Antigen - genetics
AC133 Antigen - metabolism
Adult
Aged
biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
CD133
colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
ezrin
Female
Gene Expression Regulation, Neoplastic
Humans
immunohistochemistry
Lymphatic Metastasis - pathology
Male
Middle Aged
Prognosis
ROC Curve
RT‐PCR
Up-Regulation
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Summary:Despite the improvement in the diagnostic and the therapeutic modalities, colorectal cancer (CRC) morbidity and mortality remain high in both the developed and the developing countries. So, we are in a need to recognize new efficient diagnostic and prognostic biomarkers of CRC. That may help in providing individualized targeted therapy for this lethal malignancy. In this study, we investigated the expression and the prognostic significance of CD133 and ezrin mRNA and protein by quantitative RT‐PCR and immunohistochemical analysis in primary CRC cases and the surrounding normal colonic mucosa. The correlations between the expression of both markers and clinicopathological parameters were performed. Compared to control, the expression of CD133 and ezrin mRNA and protein in CRC were significantly up‐regulated (P 
ISSN:1521-6543
1521-6551
DOI:10.1002/iub.1609