17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107

A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure w...

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Bibliographic Details
Published in:Chinese journal of natural medicines 2016-12, Vol.14 (12), p.931-933
Main Authors: LIU, Meng-Yu-Jie, LI, Shan-Ren, Chun-Hua, LU
Format: Article
Language:English
Subjects:
17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Bacteria - drug effects
Diterpenes
Diterpenes - chemistry
Diterpenes - metabolism
Diterpenes - pharmacology
Esters - chemistry
Esters - pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Streptomyces - chemistry
Streptomyces sp. SR107
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Summary:A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (1H NMR, 13C NMR, 1H-1H COSY, HSQC, HMBC, NOESY, IR and HR-ESI-MS). The antibacterial activity was also evaluated in this paper.
ISSN:1875-5364
1875-5364
DOI:10.1016/S1875-5364(17)30018-3