Short-term Changes in Gal 3 Circulating Levels After Acute Myocardial Infarction

• Published in: Archives of medical research 2016-10, Vol.47 (7), p.521-525
• Main Authors: Bivona, Giulia, Bellia, Chiara, Lo Sasso, Bruna, Agnello, Luisa, Scazzone, Concetta, Novo, Giuseppina, Ciaccio, Marcello
• Format: Article
• Language: English
• Subjects: Aged; AMI; Biomarkers - blood; CAD; Coronary Artery Disease - blood; Coronary Artery Disease - physiopathology; Female; Galectin 3; Galectin 3 - blood; Humans; Inflammation; Internal Medicine; Male; Middle Aged; Myocardial Infarction - blood; Myocardial Infarction - physiopathology; Plaque; Time Factors
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2016.12.009

Background and Aims Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. Methods Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2.8; mean age: 65.4 ± 13.8 years) were enrolled in the present study; two blood samples were collected from each patient: first, within 1 h from admission to the Emergency Area (T1) and then upon discharge (T2). Results Kinetics of Gal 3 during AMI show that the marker boosts during the acute event (T1) and then decreases from baseline, being significantly lower at T2 (18 [14.2–25] vs. 16.8 [12.7–23.4]; p  = 0.006). Gal 3 levels were correlated to hsTnI and eGFR on admission ( r  = 0.2; p