Biomedical applications of multifunctional gold-based nanocomposites

Active application of gold nanoparticles for various diagnostic and therapeutic purposes started in recent decades due to the emergence of new data on their unique optical and physicochemical properties. In addition to colloidal gold conjugates, growth in the number of publications devoted to the sy...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2016-12, Vol.81 (13), p.1771-1789
Main Authors: Dykman, L. A., Khlebtsov, N. G.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedical engineering
Biomedical materials
Biomedicine
Bioorganic Chemistry
Colloids
Conjugates
Data processing
Diagnostic software
Diagnostic systems
Documents
Emergence
Gold
Gold - chemistry
Gold - therapeutic use
Humans
Life Sciences
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Metal Nanoparticles - ultrastructure
Microbiology
Nanocomposites
Nanoparticles
Optical properties
Physicochemical properties
Review
Therapeutic applications
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Summary:Active application of gold nanoparticles for various diagnostic and therapeutic purposes started in recent decades due to the emergence of new data on their unique optical and physicochemical properties. In addition to colloidal gold conjugates, growth in the number of publications devoted to the synthesis and application of multifunctional nanocomposites has occurred in recent years. This review considers the application in biomedicine of multifunctional nanoparticles that can be produced in three different ways. The first method involves design of composite nanostructures with various components intended for either diagnostic or therapeutic functions. The second approach uses new bioconjugation techniques that allow functionalization of gold nanoparticles with various molecules, thus combining diagnostic and therapeutic functions in one medical procedure. Finally, the third method for production of multifunctional nanoparticles combines the first two approaches, in which a composite nanoparticle is additionally functionalized by molecules having different properties.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297916130125