Telomerase Is Regulated by c-Jun NH sub(2)-Terminal Kinase in Ovarian Surface Epithelial Cells

Telomerase activity is present in >90% of all tumors and appears to be regulated by the phosphatidylinositol 3-kinase signaling pathway. Here we demonstrate that Akt is not involved in the signaling cascade for telomerase regulation in ovarian surface epithelial cells. However, we showed that c-J...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2002-08, Vol.62 (16), p.4575-4578
Main Authors: Alfonso-De Matte, MY, Yang, H, Evans, MS, Cheng, J Q, Kruk, P A
Format: Article
Language:English
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Summary:Telomerase activity is present in >90% of all tumors and appears to be regulated by the phosphatidylinositol 3-kinase signaling pathway. Here we demonstrate that Akt is not involved in the signaling cascade for telomerase regulation in ovarian surface epithelial cells. However, we showed that c-Jun NH sub(2)-kinase induces telomerase activity, that inhibition of JNK by JIP abrogates telomerase activity, and that JNK expression activates transcription of a reporter gene fused to the hTERT promoter sequence. Consequently, our data show that JNK is a key regulator of telomerase activity and, hence, may provide new perspectives on tumorigenesis that could be exploited for novel therapeutic strategies.
ISSN:0008-5472