Low Testosterone Levels Result in Decreased Periurethral Vascularity via an Androgen Receptor-mediated Process: Pilot Study in Urethral Stricture Tissue

Objective To compare expression of androgen receptor (AR) and angiopoietin 1 receptor TIE-2 and vessel density of urethral stricture tissue among eugonadal and hypogonadal men to identify a pathophysiological basis for our observations that low testosterone is associated with urethral atrophy. Metho...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2017-07, Vol.105, p.175-180
Main Authors: Hofer, Matthias D, Kapur, Payal, Cordon, Billy H, Hamoun, Farrah, Russell, David, Scott, Jeremy M, Roehrborn, Claus G, Morey, Allen F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Humans
Hypogonadism - complications
Hypogonadism - metabolism
Male
Middle Aged
Pilot Projects
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Receptor, TIE-2 - metabolism
Receptors, Androgen - metabolism
Retrospective Studies
Testosterone - blood
Urethra - blood supply
Urethral Stricture - etiology
Urethral Stricture - metabolism
Urology
Young Adult
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Summary:Objective To compare expression of androgen receptor (AR) and angiopoietin 1 receptor TIE-2 and vessel density of urethral stricture tissue among eugonadal and hypogonadal men to identify a pathophysiological basis for our observations that low testosterone is associated with urethral atrophy. Methods Among 1200 men having urethroplasty at our institution, we retrospectively identified 11 patients with testosterone levels drawn within 2 years of surgery. Low testosterone was defined as
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2017.02.037