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Systematic review and meta‐analysis of health‐related quality of life in pediatric CNS tumor survivors
Background Pediatric central nervous system (CNS) tumor survivors are at high risk for numerous late effects including decreased health‐related quality of life (HRQOL). Our objective was to summarize studies describing HRQOL in pediatric CNS tumor survivors and compare HRQOL outcomes in studies that...
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Published in: | Pediatric blood & cancer 2017-08, Vol.64 (8), p.n/a |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Pediatric central nervous system (CNS) tumor survivors are at high risk for numerous late effects including decreased health‐related quality of life (HRQOL). Our objective was to summarize studies describing HRQOL in pediatric CNS tumor survivors and compare HRQOL outcomes in studies that included a comparison group.
Procedure
EMBASE, MEDLINE, and PsychINFO were used to identify relevant articles published until August, 2016. Eligible studies reported outcomes for pediatric CNS tumor survivors diagnosed before age 21, at least 5 years from diagnosis and/or 2 years off therapy and used a standardized measure of HRQOL. All data were ed by two reviewers. Random‐effects meta‐analyses were performed using Review Manager 5.0.
Results
Of 1,912 unique articles identified, 74 were included in this review. Papers described 29 different HRQOL tools. Meta‐analyses compared pediatric CNS tumor survivors to healthy comparisons and other pediatric cancer survivors separately. HRQOL was significantly lower for CNS (n = 797) than healthy comparisons (n = 1,397) (mean difference = –0.54, 95% confidence interval [CI] = –0.72 to –0.35, P < 0.001, I2 = 35%). HRQOL was also significantly lower for CNS (n = 244) than non‐CNS survivors (n = 414) (mean difference = –0.56, 95% CI = –0.73 to –0.38, P < 0.00001, I2 = 0%).
Conclusions
Pediatric CNS tumor survivors experience worse HRQOL than healthy comparisons and non‐CNS cancer survivors. Future HRQOL work should be longitudinal, and/or multisite studies that examine HRQOL by diagnosis and treatment modalities. |
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ISSN: | 1545-5009 1545-5017 |
DOI: | 10.1002/pbc.26442 |