Nanoporous membrane robustness / stability in small form factor microfluidic filtration system

The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high t...

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Bibliographic Details
Published in:2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2016-08, Vol.2016, p.1955-1958
Main Authors: Johnson, Dean G., Pan, Sabrina, Hayden, Andrew, McGrath, James L.
Format: Article
Language:English
Subjects:
Biomembranes
Blood
Fluids
Gaskets
Geometry
High definition video
Pumps
Online Access:Get full text
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Summary:The development of wearable hemodialysis (HD) devices that replace center-based HD holds the promise to improve both outcomes and quality-of-life for patients with end-stage-renal disease (ERD). A prerequisite for these devices is the development of highly efficient membranes that can achieve high toxin clearance in small footprints. The ultrathin nanoporous membrane material developed by our group is orders of magnitude more permeable than conventional HD membranes. We report on our progress making a prototype wearable dialysis unit. First, we present data from benchtop studies confirming that clinical levels of urea clearance can be obtained in a small animal model with low blood flow rates. Second, we report on efforts to improve the mechanical robustness of high membrane area dialysis devices.
ISSN:1557-170X
2694-0604
DOI:10.1109/EMBC.2016.7591106