Low Iron Stores in Otherwise Healthy Children Affect Electrocardiographic Markers of Important Cardiac Events

• Published in: Pediatric cardiology 2017-06, Vol.38 (5), p.909-914
• Main Authors: Karadeniz, Cem, Özdemir, Rahmi, Demirol, Mustafa, Katipoğlu, Nagehan, Yozgat, Yılmaz, Meşe, Timur, Ünal, Nurettin
• Format: Article
• Language: English
• Subjects: Adolescent; Anemia, Iron-Deficiency - blood; Anemia, Iron-Deficiency - complications; Arrhythmia; Arrhythmia in children; Arrhythmias, Cardiac - blood; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - etiology; Biomarkers - blood; Cardiac patients; Cardiac Surgery; Cardiology; Child; Child, Preschool; Children's furniture; Electrocardiogram; Electrocardiography; Female; Ferritin; Ferritins - blood; Humans; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Original Article; Pediatric cardiology; Prospective Studies; Vascular Surgery
• ISSN: 0172-0643; 1432-1971
• DOI: 10.1007/s00246-017-1596-7

Both an excess of iron and iron deficiency (ID) may lead to significant cardiac problems. Parameters that represent ventricular repolarization heterogeneity, like QT dispersion (QTd), corrected QT dispersion (QTcd), the interval between the peak and the end of the T wave (Tp-e), and Tp-e dispersion, have not been evaluated in otherwise healthy children with low iron levels before. Here we assessed the effects of low iron storage on P wave dispersion (PWd), QTd, Tp-e intervals, and Tp-e dispersion in otherwise healthy children. We prospectively reviewed 283 patients who were referred to pediatric cardiology department for cardiac evaluation due to murmurs and who were found to have no structural heart disease. The patients were divided into three groups according to their ferritin levels: Group 1: ferritin 25 ng/mL ( n  = 145). P wave duration (PW), QT and Tp-e intervals, and PW, QT, corrected QT (QTc), and Tp-e dispersions were significantly higher in patients whose ferritin level was