Dopamine D2 (DAD2) and dopamine D3 (DAD3) receptor gene polymorphisms and treatment outcome in alcohol dependence

The dopaminergic system is critically involved in reward mechanisms mediating the reinforcing effects of alcohol. The intention of this study was to investigate the genotypic frequencies of the -141C Ins/Del polymorphism of the DAD2 receptor gene as well as the Bal I polymorphism of the DAD3 recepto...

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Bibliographic Details
Published in:Journal of Neural Transmission 2003-07, Vol.110 (7), p.813-820
Main Authors: WIESBECK, G. A, WEIJERS, H.-G, WODARZ, N, HERRMANN, M. J, JOHANN, M, KELLER, H. K, MICHEL, T. M, BÖNING, J
Format: Article
Language:English
Subjects:
Adult
Alcoholism - genetics
Alleles
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Dopamine D2 - genetics
Receptors, Dopamine D3
Recurrence
Treatment Outcome
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Summary:The dopaminergic system is critically involved in reward mechanisms mediating the reinforcing effects of alcohol. The intention of this study was to investigate the genotypic frequencies of the -141C Ins/Del polymorphism of the DAD2 receptor gene as well as the Bal I polymorphism of the DAD3 receptor and their potential association with treatment outcome in alcoholism. Therefore, individuals suffering from primary alcohol dependence were clinically and genetically characterized and followed prospectively over a period of one year after inpatient treatment. No association was found between DAD2 or DAD3 receptor gene variants and treatment outcome as reflected by abstinence/relapse after one year. Taking into account potential stratification effects, such as family history, gender, age of onset, or severity of the disease an association with DAD2 or DAD3 gene variants could neither be found. In conclusion, we found no evidence that the DAD2 or DAD3 gene variants investigated have a major influence on treatment outcome in primary alcohol dependence.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-003-0821-0