Colonization for the Prevention of Clostridium difficile Disease in Hamsters

Studies suggest that asymptomatic colonization with Clostridium difficile (CD) decreases the risk of CD-associated disease (CDAD) in humans. A hamster model was used to test the efficacy of colonization with 3 nontoxigenic CD strains for preventing CDAD after exposure to toxigenic CD. Groups of 10 h...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2002-12, Vol.186 (12), p.1781-1789
Main Authors: Sambol, Susan P., Merrigan, Michelle M., Tang, Janet K., Johnson, Stuart, Gerding, Dale N.
Format: Article
Language:English
Subjects:
Animal bacterial diseases
Animals
Anti-Bacterial Agents - administration & dosage
Antibiotics
Bacterial diseases
Bacterial Toxins - metabolism
Biological and medical sciences
Certificates of deposit
Clindamycin - administration & dosage
Clostridium difficile
Cricetinae
Cytotoxins - metabolism
Disease Models, Animal
Dosage
Enterocolitis, Pseudomembranous - microbiology
Enterocolitis, Pseudomembranous - prevention & control
Infections
Infectious diseases
Inoculation
Major Article
Medical sciences
Mesocricetus
Microbial colonization
Preventive medicine
Probiotics - therapeutic use
Spores
Time Factors
Toxins
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies suggest that asymptomatic colonization with Clostridium difficile (CD) decreases the risk of CD-associated disease (CDAD) in humans. A hamster model was used to test the efficacy of colonization with 3 nontoxigenic CD strains for preventing CDAD after exposure to toxigenic CD. Groups of 10 hamsters were given 106 nontoxigenic CD spores 2 days after receiving a single dose of clindamycin. Five days later, the hamsters were given 100 spores of 1 of 3 toxigenic CD strains previously shown to cause mortality within 48 h. Each nontoxigenic strain prevented disease in 87%–97% of hamsters that were challenged with toxigenic strains. Failure to prevent CDAD was associated with failure of colonization with nontoxigenic CD. Colonization with nontoxigenic CD strains is highly effective in preventing CDAD in hamsters challenged with toxigenic CD strains, which suggests that use of a probiotic strategy for CDAD prevention in humans receiving antibiotics might be beneficial
ISSN:0022-1899
1537-6613
DOI:10.1086/345676