Weight reduction and long-term maintenance after 18 months treatment with orlistat for obesity

OBJECTIVE: To determine the effect of orlistat on weight reduction and the long-term maintenance of this weight loss when associated with a continuous mildly reduced energy diet. DESIGN: A multicenter, 18-month, double-blind study conducted in 81 hospital centers. Patients were randomized to orlista...

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Bibliographic Details
Published in:International Journal of Obesity 2003-05, Vol.27 (5), p.591-597
Main Authors: Krempf, M, Louvet, J-P, Allanic, H, Miloradovich, T, Joubert, J-M, Attali, J-R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood pressure
Body mass index
Body weight
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Diagnosis
Diaries
Diet
Dietary restrictions
Dosage and administration
Drug therapy
Energy
Epidemiology
Food
Health aspects
Health Promotion and Disease Prevention
Internal Medicine
Low density lipoprotein
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Methods
Nutrition research
Obesity
Orlistat
Overweight
Patients
Public Health
Risk factors
Statistical power
Weight control
Weight loss
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Summary:OBJECTIVE: To determine the effect of orlistat on weight reduction and the long-term maintenance of this weight loss when associated with a continuous mildly reduced energy diet. DESIGN: A multicenter, 18-month, double-blind study conducted in 81 hospital centers. Patients were randomized to orlistat 120 mg or placebo three times daily in conjunction with a mildly reduced-energy diet maintained throughout the study. SUBJECTS: In total, 696 otherwise healthy, overweight patients aged 18–65 y (BMI ≥28 kg/m 2 ) were randomized to treatment with orlistat ( n =346) or placebo ( n =350). MEASUREMENTS: Body weight, anthropometry, lipid and glycemic control parameters and blood pressure. RESULTS: After 18 months, patients treated with orlistat lost significantly more body weight compared with placebo (−6.5±0.8 vs −3.0±0.8%; P =0.0005). After 12 months, 32.9% of orlistat vs 24.5% of placebo patients lost ≥10% of their initial weight ( P =0.04). A significantly greater number of patients receiving orlistat treatment maintained this ≥10% weight loss compared to those receiving placebo (28.1 vs 13.8%; P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802281