beta -Adrenergic receptor blockade impairs NO-dependent dilation of large coronary arteries during exercise

Institut de Cardiologie de Montréal and Department of Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada H1T 1C8 Shear stress-dependent nitric oxide (NO) formation prevents immoderate vascular constriction. We examined whether shear stress-dependent NO formation limits...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2003-02, Vol.284 (2), p.H501-H510
Main Authors: Okajima, Masaki, Takamura, Masayuki, Vequaud, Philippe, Parent, Robert, Lavallee, Michel
Format: Article
Language:English
Subjects:
Adenosine - administration & dosage
Adenosine - pharmacology
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - pharmacology
Animals
Arteries
Coronary Vessels - physiology
Dogs
Enzyme Inhibitors - pharmacology
Hemodynamics - drug effects
Injections, Intra-Arterial
Motor Activity - physiology
NG-Nitroarginine Methyl Ester - pharmacology
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - physiology
Nitroarginine - pharmacology
Nitroglycerin - administration & dosage
Nitroglycerin - pharmacology
Propranolol - pharmacology
Vasodilation - drug effects
Vasodilation - physiology
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Summary:Institut de Cardiologie de Montréal and Department of Physiology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada H1T 1C8 Shear stress-dependent nitric oxide (NO) formation prevents immoderate vascular constriction. We examined whether shear stress-dependent NO formation limits exercise-induced coronary artery constriction after -adrenergic receptor blockade in dogs. Control exercise led to increases ( P  
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00419.2002