Determination of octanol–water partition coefficients of pesticides by microemulsion electrokinetic chromatography

• Published in: Journal of Chromatography A 2001-09, Vol.930 (1), p.145-154
• Main Authors: Klotz, W.L., Schure, M.R., Foley, J.P.
• Format: Article
• Language: English
• Subjects: Analytical chemistry; Calibration; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography, Micellar Electrokinetic Capillary - methods; Emulsions; Exact sciences and technology; Octanols - chemistry; Other chromatographic methods; Pesticides; Pesticides - analysis; Water - chemistry
• ISSN: 0021-9673
• DOI: 10.1016/S0021-9673(01)01171-2

Microemulsion electrokinetic chromatography (MEEKC) was evaluated as a screening tool for the indirect measurement of octanol–water partition coefficients (log P o/w) of pesticide compounds. Over 80 pesticide compounds representing a variety of structural characteristics were studied, and good correlation of log P o/w with the logarithm of the retention factor was found. The microemulsion system studied allowed the separation of compounds in the log P o/w range of −1 to 7. In addition, a smaller set of simple organic molecules that vary in structural features was evaluated and compared to the pesticide log P o/w calibration. The pesticide and simple organic molecule log P o/w calibration lines were statistically similar. This suggests that a universal set of standard compounds may be employed for the log P o/w calibration to provide measurements for a variety of compounds with good accuracy.