Topical tamoxifen in the therapy of cutaneous leishmaniasis

The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Leishmania amazone...

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Bibliographic Details
Published in:Parasitology 2018-04, Vol.145 (4), p.490-496
Main Authors: TRINCONI, CRISTIANA T., REIMÃO, JULIANA Q., BONANO, VIVIAN I., ESPADA, CAROLINE R., MIGUEL, DANILO C., YOKOYAMA-YASUNAKA, JENICER K. U., ULIANA, SILVIA R. B.
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antimicrobial agents
Antiprotozoal Agents - administration & dosage
Antiprotozoal Agents - adverse effects
Antiprotozoal Agents - therapeutic use
Chemotherapy
Cream
Cutaneous leishmaniasis
Drug Therapy, Combination - adverse effects
Drugs
Ethanol
Ethanol - chemistry
Experiments
Female
Formulations
Infections
Infectious diseases
Leishmania
Leishmania amazonensis
Leishmania mexicana - drug effects
Leishmania mexicana - enzymology
Leishmania mexicana - genetics
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - parasitology
Lesions
Luciferases - genetics
Luminescence
Meglumine Antimoniate - administration & dosage
Meglumine Antimoniate - therapeutic use
Mice
Mice, Inbred BALB C
Parasites
Parasitic diseases
Skin - drug effects
Skin - parasitology
Skin Cream - administration & dosage
Skin Cream - adverse effects
Skin Cream - therapeutic use
Tamoxifen
Tamoxifen - administration & dosage
Tamoxifen - adverse effects
Tamoxifen - chemistry
Tamoxifen - therapeutic use
Vector-borne diseases
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Summary:The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial combinations in an experimental model of cutaneous leishmaniasis. BALB/c mice infected with a luciferase expressing line of Leishmania amazonensis were treated with topical tamoxifen in two different formulations (ethanol or oil-free cream) as monotherapy or in co-administration with pentavalent antimonial. Treatment efficacy was evaluated by lesion size and parasite burden, quantified through luminescence, at the end of treatment and 4 weeks later. Topical tamoxifen, formulated in ethanol or as a cream, was shown to be effective. The interaction between tamoxifen and pentavalent antimonial was additive in vitro. Treatment with combined schemes containing tamoxifen and pentavalent antimonial was effective in reducing lesion size and parasite burden. Co-administration of tamoxifen and pentavalent antimonial was superior to monotherapy with antimonial.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182017000130