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Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity
This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coup...
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| Published in: | Environmental pollution (1987) 2017-05, Vol.224, p.224-234 |
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| Main Authors: | , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c362t-390eda3ee0509002e2b7ea1378024f8fa030f94b6e06c85d298d38f19dd9f5bc3 |
| container_end_page | 234 |
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| container_start_page | 224 |
| container_title | Environmental pollution (1987) |
| container_volume | 224 |
| creator | Wang, Yi-Xin Wang, Peng Feng, Wei Liu, Chong Yang, Pan Chen, Ying-Jun Sun, Li Sun, Yang Yue, Jing Gu, Long-Jie Zeng, Qiang Lu, Wen-Qing |
| description | This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coupled plasma-mass spectrometry among 746 men recruited from a reproductive medicine center. Associations of these metals/metalloids with semen quality (n = 746), sperm apoptosis (n = 331) and DNA integrity (n = 404) were evaluated using multivariate linear and logistic regression models. After accounting for multiple comparisons and confounders, seminal plasma arsenic (As) quartiles were negatively associated with progressive and total sperm motility using multivariable linear regression analysis, which were in accordance with the trends for increased odds ratios (ORs) for below-reference semen quality parameters in the logistic models. We also found inverse correlations between cadmium (Cd) quartiles and progressive and total sperm motility, whereas positive correlations between zinc (Zn) quartiles and sperm concentration, between copper (Cu) and As quartiles and the percentage of tail DNA, between As and selenium (Se) quartiles and tail extent and tail distributed moment, and between tin (Sn) categories and the percentage of necrotic spermatozoa (all Ptrend |
| doi_str_mv | 10.1016/j.envpol.2017.01.083 |
| format | article |
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[Display omitted]
•Seminal plasma As and Cd were inversely associated with sperm motility.•Zn in seminal plasma was associated with increasing sperm concentration.•We found positive correlations between As, Se and Cu and sperm DNA damage.•Seminal plasma Sn was associated with increasing percentage of necrotic sperm.
Our results strengthen the evidence that environmental exposure to As, Cd, Cu, Se and Sn may impair human reproductive health.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2017.01.083</identifier><identifier>PMID: 28274591</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Apoptosis ; Apoptosis - drug effects ; Biomarkers - analysis ; China ; DNA Damage - drug effects ; DNA integrity ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Epidemiology ; Humans ; Infertility, Male ; Male ; Metalloids - adverse effects ; Metalloids - analysis ; Metals - adverse effects ; Metals - analysis ; Oxidative Stress - drug effects ; Reproductive Health ; Semen - cytology ; Semen - drug effects ; Semen - metabolism ; Semen Analysis ; Semen quality ; Seminal plasma metals/metalloids ; Sperm Count ; Sperm Motility - drug effects ; Spermatozoa - cytology ; Spermatozoa - drug effects ; Spermatozoa - metabolism ; Spermatozoa - pathology</subject><ispartof>Environmental pollution (1987), 2017-05, Vol.224, p.224-234</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-390eda3ee0509002e2b7ea1378024f8fa030f94b6e06c85d298d38f19dd9f5bc3</citedby><cites>FETCH-LOGICAL-c362t-390eda3ee0509002e2b7ea1378024f8fa030f94b6e06c85d298d38f19dd9f5bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28274591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yi-Xin</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Liu, Chong</creatorcontrib><creatorcontrib>Yang, Pan</creatorcontrib><creatorcontrib>Chen, Ying-Jun</creatorcontrib><creatorcontrib>Sun, Li</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Yue, Jing</creatorcontrib><creatorcontrib>Gu, Long-Jie</creatorcontrib><creatorcontrib>Zeng, Qiang</creatorcontrib><creatorcontrib>Lu, Wen-Qing</creatorcontrib><title>Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coupled plasma-mass spectrometry among 746 men recruited from a reproductive medicine center. Associations of these metals/metalloids with semen quality (n = 746), sperm apoptosis (n = 331) and DNA integrity (n = 404) were evaluated using multivariate linear and logistic regression models. After accounting for multiple comparisons and confounders, seminal plasma arsenic (As) quartiles were negatively associated with progressive and total sperm motility using multivariable linear regression analysis, which were in accordance with the trends for increased odds ratios (ORs) for below-reference semen quality parameters in the logistic models. We also found inverse correlations between cadmium (Cd) quartiles and progressive and total sperm motility, whereas positive correlations between zinc (Zn) quartiles and sperm concentration, between copper (Cu) and As quartiles and the percentage of tail DNA, between As and selenium (Se) quartiles and tail extent and tail distributed moment, and between tin (Sn) categories and the percentage of necrotic spermatozoa (all Ptrend<0.05). These relationships remained after the simultaneous consideration of various elements. Our results indicate that environmental exposure to As, Cd, Cu, Se and Sn may impair male reproductive health, whereas Zn may be beneficial to sperm concentration.
[Display omitted]
•Seminal plasma As and Cd were inversely associated with sperm motility.•Zn in seminal plasma was associated with increasing sperm concentration.•We found positive correlations between As, Se and Cu and sperm DNA damage.•Seminal plasma Sn was associated with increasing percentage of necrotic sperm.
Our results strengthen the evidence that environmental exposure to As, Cd, Cu, Se and Sn may impair human reproductive health.</description><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biomarkers - analysis</subject><subject>China</subject><subject>DNA Damage - drug effects</subject><subject>DNA integrity</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Epidemiology</subject><subject>Humans</subject><subject>Infertility, Male</subject><subject>Male</subject><subject>Metalloids - adverse effects</subject><subject>Metalloids - analysis</subject><subject>Metals - adverse effects</subject><subject>Metals - analysis</subject><subject>Oxidative Stress - drug effects</subject><subject>Reproductive Health</subject><subject>Semen - cytology</subject><subject>Semen - drug effects</subject><subject>Semen - metabolism</subject><subject>Semen Analysis</subject><subject>Semen quality</subject><subject>Seminal plasma metals/metalloids</subject><subject>Sperm Count</subject><subject>Sperm Motility - drug effects</subject><subject>Spermatozoa - cytology</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - metabolism</subject><subject>Spermatozoa - pathology</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1P3DAURS3UqgzQf4BQll2Q8Pwxib1BQkApEmqlqqwtJ35pPThxsD0g_n0zBLrs6m3OvVfvEHJMoaJA67NNhePTFHzFgDYV0Aok3yMrKhte1oKJD2QFrFZlIxTdJwcpbQBAcM4_kX0mWSPWiq7Iw0_0Jrswpj9uSkWL-RlxLBIObjS-mLxJgykGzMans9fjg7OpMKPdQTP6uDXe5ZfTIk0Yh8JMYcohuQW5-n5RuDHj7zgjR-RjP9fg57d7SO6_Xv-6_Fbe_bi5vby4Kztes1xyBWgNR4Q1KACGrG3QUN5IYKKXvQEOvRJtjVB3cm2ZkpbLniprVb9uO35Iviy9UwyPW0xZDy516L0ZMWyTnhXVQnEp-YyKBe1iSClir6foBhNfNAW906w3etGsd5o1UA2vsZO3hW07oP0Xevc6A-cLgPOfTw6jTp3DsUPrInZZ2-D-v_AXlGKSPQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Wang, Yi-Xin</creator><creator>Wang, Peng</creator><creator>Feng, Wei</creator><creator>Liu, Chong</creator><creator>Yang, Pan</creator><creator>Chen, Ying-Jun</creator><creator>Sun, Li</creator><creator>Sun, Yang</creator><creator>Yue, Jing</creator><creator>Gu, Long-Jie</creator><creator>Zeng, Qiang</creator><creator>Lu, Wen-Qing</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity</title><author>Wang, Yi-Xin ; Wang, Peng ; Feng, Wei ; Liu, Chong ; Yang, Pan ; Chen, Ying-Jun ; Sun, Li ; Sun, Yang ; Yue, Jing ; Gu, Long-Jie ; Zeng, Qiang ; Lu, Wen-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-390eda3ee0509002e2b7ea1378024f8fa030f94b6e06c85d298d38f19dd9f5bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biomarkers - analysis</topic><topic>China</topic><topic>DNA Damage - drug effects</topic><topic>DNA integrity</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Exposure - analysis</topic><topic>Epidemiology</topic><topic>Humans</topic><topic>Infertility, Male</topic><topic>Male</topic><topic>Metalloids - adverse effects</topic><topic>Metalloids - analysis</topic><topic>Metals - adverse effects</topic><topic>Metals - analysis</topic><topic>Oxidative Stress - drug effects</topic><topic>Reproductive Health</topic><topic>Semen - cytology</topic><topic>Semen - drug effects</topic><topic>Semen - metabolism</topic><topic>Semen Analysis</topic><topic>Semen quality</topic><topic>Seminal plasma metals/metalloids</topic><topic>Sperm Count</topic><topic>Sperm Motility - drug effects</topic><topic>Spermatozoa - cytology</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - metabolism</topic><topic>Spermatozoa - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yi-Xin</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Liu, Chong</creatorcontrib><creatorcontrib>Yang, Pan</creatorcontrib><creatorcontrib>Chen, Ying-Jun</creatorcontrib><creatorcontrib>Sun, Li</creatorcontrib><creatorcontrib>Sun, Yang</creatorcontrib><creatorcontrib>Yue, Jing</creatorcontrib><creatorcontrib>Gu, Long-Jie</creatorcontrib><creatorcontrib>Zeng, Qiang</creatorcontrib><creatorcontrib>Lu, Wen-Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yi-Xin</au><au>Wang, Peng</au><au>Feng, Wei</au><au>Liu, Chong</au><au>Yang, Pan</au><au>Chen, Ying-Jun</au><au>Sun, Li</au><au>Sun, Yang</au><au>Yue, Jing</au><au>Gu, Long-Jie</au><au>Zeng, Qiang</au><au>Lu, Wen-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>224</volume><spage>224</spage><epage>234</epage><pages>224-234</pages><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>This study aimed to investigate the relationships between environmental exposure to metals/metalloids and semen quality, sperm apoptosis and DNA integrity using the metal/metalloids levels in seminal plasma as biomarkers. We determined 18 metals/metalloids in seminal plasma using an inductively coupled plasma-mass spectrometry among 746 men recruited from a reproductive medicine center. Associations of these metals/metalloids with semen quality (n = 746), sperm apoptosis (n = 331) and DNA integrity (n = 404) were evaluated using multivariate linear and logistic regression models. After accounting for multiple comparisons and confounders, seminal plasma arsenic (As) quartiles were negatively associated with progressive and total sperm motility using multivariable linear regression analysis, which were in accordance with the trends for increased odds ratios (ORs) for below-reference semen quality parameters in the logistic models. We also found inverse correlations between cadmium (Cd) quartiles and progressive and total sperm motility, whereas positive correlations between zinc (Zn) quartiles and sperm concentration, between copper (Cu) and As quartiles and the percentage of tail DNA, between As and selenium (Se) quartiles and tail extent and tail distributed moment, and between tin (Sn) categories and the percentage of necrotic spermatozoa (all Ptrend<0.05). These relationships remained after the simultaneous consideration of various elements. Our results indicate that environmental exposure to As, Cd, Cu, Se and Sn may impair male reproductive health, whereas Zn may be beneficial to sperm concentration.
[Display omitted]
•Seminal plasma As and Cd were inversely associated with sperm motility.•Zn in seminal plasma was associated with increasing sperm concentration.•We found positive correlations between As, Se and Cu and sperm DNA damage.•Seminal plasma Sn was associated with increasing percentage of necrotic sperm.
Our results strengthen the evidence that environmental exposure to As, Cd, Cu, Se and Sn may impair human reproductive health.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28274591</pmid><doi>10.1016/j.envpol.2017.01.083</doi><tpages>11</tpages></addata></record> |
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| ispartof | Environmental pollution (1987), 2017-05, Vol.224, p.224-234 |
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| source | ScienceDirect Freedom Collection |
| subjects | Apoptosis Apoptosis - drug effects Biomarkers - analysis China DNA Damage - drug effects DNA integrity Environmental Exposure - adverse effects Environmental Exposure - analysis Epidemiology Humans Infertility, Male Male Metalloids - adverse effects Metalloids - analysis Metals - adverse effects Metals - analysis Oxidative Stress - drug effects Reproductive Health Semen - cytology Semen - drug effects Semen - metabolism Semen Analysis Semen quality Seminal plasma metals/metalloids Sperm Count Sperm Motility - drug effects Spermatozoa - cytology Spermatozoa - drug effects Spermatozoa - metabolism Spermatozoa - pathology |
| title | Relationships between seminal plasma metals/metalloids and semen quality, sperm apoptosis and DNA integrity |
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