Diagnostic significance of serum concentrations of soluble Fas ligand (sFasL) in children with autoimmune thyroid disease

Introduction: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD). Design: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control gr...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2017-04, Vol.50 (3), p.192-198
Main Authors: Mikos, Hanna, Mikos, Marcin, Niedziela, Marek
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Area Under Curve
Autoantibodies - blood
Autoantibodies - immunology
Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
autoimmune thyroid disease
Biomarkers
Case-Control Studies
Child
Child, Preschool
children
Fas Ligand Protein - blood
Female
Graves' disease
Hashimoto's thyroiditis
Humans
Male
ROC Curve
Soluble Fas ligand
Thyroid Diseases - blood
Thyroid Diseases - diagnosis
Thyroid Diseases - immunology
Thyroid Function Tests
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Summary:Introduction: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD). Design: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1.9 years), 19 children with hyperthyroidism (15 girls and 4 boys, aged 12.4 ± 4.9 years) and 15 healthy subjects (7 girls and 8 boys, aged 10.5 ± 4.8 years). Methods: Thyroid function (TSH, fT4, fT3), autoimmune (ATG, ATPO, TRAb) and anthropometric (weight, height, BMI, BMI-SDS, Cole index) parameters were evaluated. sFasL concentration was measured by ELISA. Nonparametric statistical test and ROC analysis were performed to assess the data. Results: We found no significant differences in serum concentrations of sFasL between boys and girls in the studied groups. Significantly higher sFasL levels (median 0.26 ng/ml) were identified in children with hypothyroidism compared with the control group (median 0.06 ng/ml, p 
ISSN:0891-6934
1607-842X
DOI:10.1080/08916934.2017.1289180