Purinergic P2 receptors in the paraventricular nucleus of the hypothalamus are involved in hyperosmotic-induced sympathoexcitation

Highlights • Increasing plasma osmolality activates P2X2-expressing neurons in the paraventricular nucleus. • Blocking P2 purinoceptors attenuate hyperosmotic activation of lumber sympathetic nerve activity. • P2 receptors are important for regulating sympathetic responses to increases in plasma osm...

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Bibliographic Details
Published in:Neuroscience 2017-05, Vol.349, p.253-263
Main Authors: Ferreira-Neto, H.C, Ribeiro, I.M.R, Moreira, T.S, Yao, S.T, Antunes, V.R
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin - metabolism
autonomic nervous system
hyperosmolality
hypertonic saline
Hypothalamus - drug effects
Hypothalamus - metabolism
Male
mannitol
Neurology
Neurons - drug effects
Neurons - metabolism
Paraventricular Hypothalamic Nucleus - drug effects
purinergic signaling
Rats, Wistar
Receptors, Purinergic P2 - metabolism
Saline Solution, Hypertonic - pharmacology
sympathetic activity
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Summary:Highlights • Increasing plasma osmolality activates P2X2-expressing neurons in the paraventricular nucleus. • Blocking P2 purinoceptors attenuate hyperosmotic activation of lumber sympathetic nerve activity. • P2 receptors are important for regulating sympathetic responses to increases in plasma osmolality.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.02.054