A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems

Mucoadhesion is a useful strategy for drug delivery systems, such as tablets, patches, gels, liposomes, micro/nanoparticles, nanosuspensions, microemulsions and colloidal dispersions. Moreover, it has contributed to many benefits like increased residence time at application sites, drug protection, i...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2017-07, Vol.43 (7), p.1053-1070
Main Authors: Bassi da Silva, Jéssica, Ferreira, Sabrina Barbosa de Souza, de Freitas, Osvaldo, Bruschi, Marcos Luciano
Format: Article
Language:English
Subjects:
Adhesiveness
Animals
bioadhesion methods
bioadhesion theories
Chemistry, Pharmaceutical
controlled release
Drug Delivery Systems - methods
Humans
Liposomes - chemistry
Mucoadhesion
Mucous Membrane - chemistry
Nanoparticles - chemistry
pharmaceutical systems
Tablets - administration & dosage
Tablets - chemistry
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Summary:Mucoadhesion is a useful strategy for drug delivery systems, such as tablets, patches, gels, liposomes, micro/nanoparticles, nanosuspensions, microemulsions and colloidal dispersions. Moreover, it has contributed to many benefits like increased residence time at application sites, drug protection, increased drug permeation and improved drug availability. In this context, investigation into the mucoadhesive properties of pharmaceutical dosage forms is fundamental, in order to characterize, understand and simulate the in vivo interaction between the formulation and the biological substrate, contributing to the development of new mucoadhesive systems with effectiveness, safety and quality. There are a lot of in vivo, in vitro and ex vivo methods for the evaluation of the mucoadhesive properties of drug delivery systems. However, there also is a lack of standardization of these techniques, which makes comparison between the results difficult. Therefore, this work aims to show an overview of the most commonly employed methods for mucoadhesion evaluation, relating them to different proposed systems and using artificial or natural mucosa from humans and animals.
ISSN:0363-9045
1520-5762
DOI:10.1080/03639045.2017.1294600