Expression of Neprilysin in Periodontitis-affected Gingival Tissues

Highlights • APP and NEP genes were up-regulated in periodontitis-affected gingival tissues. • APP expressing cells were confirmed to be macrophages in inflamed gingival tissues. • NEP was primarily expressed in neutrophils and fibroblasts in gingival tissues.

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Bibliographic Details
Published in:Archives of oral biology 2017-07, Vol.79, p.35-41
Main Authors: Nezu, A, Kubota, T, Maruyama, S, Nagata, M, Nohno, K, Morozumi, T, Yoshie, H
Format: Article
Language:English
Subjects:
Adult
Advanced Basic Science
Aged
Alzheimer Disease
Alzheimer’s disease
Amyloid beta precursor protein
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Chronic Periodontitis - diagnostic imaging
Chronic Periodontitis - genetics
Chronic Periodontitis - metabolism
Chronic Periodontitis - pathology
Dentistry
Female
Fibroblasts - metabolism
Gene expression
Gene Expression Regulation
Gingiva - diagnostic imaging
Gingiva - drug effects
Gingiva - pathology
Humans
Immunohistochemistry
Immunolocalisation
Inflammation
Interleukin-1beta - genetics
Interleukin-1beta - metabolism
Japan
Macrophages - metabolism
Male
Middle Aged
Neprilysin
Neprilysin - biosynthesis
Neprilysin - genetics
Neprilysin - pharmacology
Neutrophils - metabolism
Periodontitis
Real-Time Polymerase Chain Reaction
RNA, Messenger - biosynthesis
Up-Regulation
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Description
Summary:Highlights • APP and NEP genes were up-regulated in periodontitis-affected gingival tissues. • APP expressing cells were confirmed to be macrophages in inflamed gingival tissues. • NEP was primarily expressed in neutrophils and fibroblasts in gingival tissues.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2017.03.003