Tensile and shear methods for measuring strength of bilayer tablets

[Display omitted] Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear forc...

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Bibliographic Details
Published in:International journal of pharmaceutics 2017-05, Vol.523 (1), p.121-126
Main Authors: Chang, Shao-Yu, Li, Jian-xin, Sun, Changquan Calvin
Format: Article
Language:English
Subjects:
Bilayer
Cellulose - chemistry
Excipients - chemistry
Lactose
Lactose - chemistry
Mechanical properties
Microcrystalline cellulose
Shear
Stress, Mechanical
Tablet
Tablets - chemistry
Technology, Pharmaceutical - methods
Tensile
Tensile Strength
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Summary:[Display omitted] Both shear and tensile measurement methods have been used to quantify interfacial bonding strength of bilayer tablets. The shear method is more convenient to perform, but reproducible strength data requires careful control of the placement of tablet and contact point for shear force application. Moreover, data obtained from the shear method depend on the orientation of the bilayer tablet. Although more time-consuming to perform, the tensile method yields data that are straightforward to interpret. Thus, the tensile method is preferred in fundamental bilayer tableting research to minimize ambiguity in data interpretation. Using both shear and tensile methods, we measured the mechanical strength of bilayer tablets made of several different layer combinations of lactose and microcrystalline cellulose. We observed a good correlation between strength obtained by the tensile method and carefully conducted shear method. This suggests that the shear method may be used for routine quality test of bilayer tablets during manufacturing because of its speed and convenience, provided a protocol for careful control of the placement of the tablet interface, tablet orientation, and blade is implemented.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2017.03.010