GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma

Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated th...

Full description

Saved in:
Bibliographic Details
Published in:Urologic oncology 2017-06, Vol.35 (6), p.409-417
Main Authors: Coric, Vesna M., M.D, Simic, Tatjana P., M.D., Ph.D, Pekmezovic, Tatjana D., M.D., Ph.D, Basta-Jovanovic, Gordana M., M.D., Ph.D, Savic-Radojevic, Ana R., M.D., Ph.D, Radojevic-Skodric, Sanja M., M.D., Ph.D, Matic, Marija G., M.D., Ph.D, Suvakov, Sonja R., M.D., Ph.D, Dragicevic, Dejan P., M.D., Ph.D, Radic, Tanja M., M.Sc, Dzamic, Zoran M., M.D., Ph.D, Pljesa-Ercegovac, Marija S., M.D., Ph.D
Format: Article
Language:English
Subjects:
Carcinoma, Renal Cell - enzymology
Carcinoma, Renal Cell - genetics
Carcinoma, Renal Cell - pathology
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Glutathione S-transferase
Glutathione Transferase - genetics
Humans
Kidney Neoplasms - enzymology
Kidney Neoplasms - genetics
Kidney Neoplasms - pathology
Male
Middle Aged
Polymorphism
Prognosis
Renal cell carcinoma
Retrospective Studies
Risk
Survival
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear cell RCC (ccRCC). Methods GST genotypes were determined in 305 patients with RCC and 326 matched controls, whereas the overall survival was evaluated in patients with ccRCC only. The presence of GSTM1:ASK1 protein-protein interaction in ccRCC tissue samples was analyzed by methods of immunoprecipitation and immunoblot. Results We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype ( P
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2017.02.005