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GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma
Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated th...
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| Published in: | Urologic oncology 2017-06, Vol.35 (6), p.409-417 |
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| creator | Coric, Vesna M., M.D Simic, Tatjana P., M.D., Ph.D Pekmezovic, Tatjana D., M.D., Ph.D Basta-Jovanovic, Gordana M., M.D., Ph.D Savic-Radojevic, Ana R., M.D., Ph.D Radojevic-Skodric, Sanja M., M.D., Ph.D Matic, Marija G., M.D., Ph.D Suvakov, Sonja R., M.D., Ph.D Dragicevic, Dejan P., M.D., Ph.D Radic, Tanja M., M.Sc Dzamic, Zoran M., M.D., Ph.D Pljesa-Ercegovac, Marija S., M.D., Ph.D |
| description | Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear cell RCC (ccRCC). Methods GST genotypes were determined in 305 patients with RCC and 326 matched controls, whereas the overall survival was evaluated in patients with ccRCC only. The presence of GSTM1:ASK1 protein-protein interaction in ccRCC tissue samples was analyzed by methods of immunoprecipitation and immunoblot. Results We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype ( P |
| doi_str_mv | 10.1016/j.urolonc.2017.02.005 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1876817279</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1078143917300662</els_id><sourcerecordid>1876817279</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-522e182da2853f09a9b2e3a06c92b4db56dd587b96ffdde502c58722533a32073</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EoqXwE0A-ckkYj_PhXECogoJUxKHt2XLsSeUlay92grT_Hke7cODCxR7L7zsfzzD2WkAtQHTvdvWa4hyDrRFEXwPWAO0TdilULytshu5piaFXlWjkcMFe5LwDEI0S4jm7QIWqUYO8ZA83d_ffBH-kEJfjgbjP3ATug6MDlSMs_JDiY4h58ZZPxi4xlV9uZzKJW5pnniiY-RRak6wPcW9esmeTmTO9Ot9X7OHzp_vrL9Xt95uv1x9vK9sgLFWLSEKhM6haOcFghhFJGujsgGPjxrZzrlX9OHTT5By1gLY8EVspjUTo5RV7e8pbmvy5Ul703uetFRMorlkXGJ0SPfZDkbYnqU0x50STPiS_N-moBeiNqN7pM1G9EdWAuhAtvjfnEuu4J_fX9QdhEXw4CagM-stT0tl6CpacT2QX7aL_b4n3_2Swsw_emvkHHSnv4poK4jKNzsWg77a1blsVvQToOpS_AR48nmI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1876817279</pqid></control><display><type>article</type><title>GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma</title><source>ScienceDirect Journals</source><creator>Coric, Vesna M., M.D ; Simic, Tatjana P., M.D., Ph.D ; Pekmezovic, Tatjana D., M.D., Ph.D ; Basta-Jovanovic, Gordana M., M.D., Ph.D ; Savic-Radojevic, Ana R., M.D., Ph.D ; Radojevic-Skodric, Sanja M., M.D., Ph.D ; Matic, Marija G., M.D., Ph.D ; Suvakov, Sonja R., M.D., Ph.D ; Dragicevic, Dejan P., M.D., Ph.D ; Radic, Tanja M., M.Sc ; Dzamic, Zoran M., M.D., Ph.D ; Pljesa-Ercegovac, Marija S., M.D., Ph.D</creator><creatorcontrib>Coric, Vesna M., M.D ; Simic, Tatjana P., M.D., Ph.D ; Pekmezovic, Tatjana D., M.D., Ph.D ; Basta-Jovanovic, Gordana M., M.D., Ph.D ; Savic-Radojevic, Ana R., M.D., Ph.D ; Radojevic-Skodric, Sanja M., M.D., Ph.D ; Matic, Marija G., M.D., Ph.D ; Suvakov, Sonja R., M.D., Ph.D ; Dragicevic, Dejan P., M.D., Ph.D ; Radic, Tanja M., M.Sc ; Dzamic, Zoran M., M.D., Ph.D ; Pljesa-Ercegovac, Marija S., M.D., Ph.D</creatorcontrib><description>Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear cell RCC (ccRCC). Methods GST genotypes were determined in 305 patients with RCC and 326 matched controls, whereas the overall survival was evaluated in patients with ccRCC only. The presence of GSTM1:ASK1 protein-protein interaction in ccRCC tissue samples was analyzed by methods of immunoprecipitation and immunoblot. Results We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype ( P <0.05). On the contrary, survival analysis indicated shorter overall survival for patients with ccRCC with GSTM1-active genotype ( P = 0.026). Furthermore, patients with ccRCC with GSTM1-active genotype had significantly higher hazard ratio ( P <0.05), in analyzed regression models, compared with the carriers of GSTM1-null genotype. Finally, the presence of GSTM1:ASK1 protein-protein interaction was found in all RCC tissue samples studied. Conclusions Carriers of GSTM1-null and GSTP1-variant genotypes are in increased risk of RCC development. On the contrary, GSTM1-null genotype is associated with favorable postoperative prognosis in ccRCC. The possible molecular mechanism underlying the role of GSTM1 protein in RCC progression might be the presence of GSTM1:ASK1 protein-protein interaction. Hence, determination of GSTM1 -genotype might serve as a valuable indicator in both RCC risk assessment and postoperative prognosis.</description><identifier>ISSN: 1078-1439</identifier><identifier>EISSN: 1873-2496</identifier><identifier>DOI: 10.1016/j.urolonc.2017.02.005</identifier><identifier>PMID: 28284893</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Carcinoma, Renal Cell - enzymology ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-transferase ; Glutathione Transferase - genetics ; Humans ; Kidney Neoplasms - enzymology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Male ; Middle Aged ; Polymorphism ; Prognosis ; Renal cell carcinoma ; Retrospective Studies ; Risk ; Survival ; Urology</subject><ispartof>Urologic oncology, 2017-06, Vol.35 (6), p.409-417</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-522e182da2853f09a9b2e3a06c92b4db56dd587b96ffdde502c58722533a32073</citedby><cites>FETCH-LOGICAL-c420t-522e182da2853f09a9b2e3a06c92b4db56dd587b96ffdde502c58722533a32073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28284893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coric, Vesna M., M.D</creatorcontrib><creatorcontrib>Simic, Tatjana P., M.D., Ph.D</creatorcontrib><creatorcontrib>Pekmezovic, Tatjana D., M.D., Ph.D</creatorcontrib><creatorcontrib>Basta-Jovanovic, Gordana M., M.D., Ph.D</creatorcontrib><creatorcontrib>Savic-Radojevic, Ana R., M.D., Ph.D</creatorcontrib><creatorcontrib>Radojevic-Skodric, Sanja M., M.D., Ph.D</creatorcontrib><creatorcontrib>Matic, Marija G., M.D., Ph.D</creatorcontrib><creatorcontrib>Suvakov, Sonja R., M.D., Ph.D</creatorcontrib><creatorcontrib>Dragicevic, Dejan P., M.D., Ph.D</creatorcontrib><creatorcontrib>Radic, Tanja M., M.Sc</creatorcontrib><creatorcontrib>Dzamic, Zoran M., M.D., Ph.D</creatorcontrib><creatorcontrib>Pljesa-Ercegovac, Marija S., M.D., Ph.D</creatorcontrib><title>GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma</title><title>Urologic oncology</title><addtitle>Urol Oncol</addtitle><description>Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear cell RCC (ccRCC). Methods GST genotypes were determined in 305 patients with RCC and 326 matched controls, whereas the overall survival was evaluated in patients with ccRCC only. The presence of GSTM1:ASK1 protein-protein interaction in ccRCC tissue samples was analyzed by methods of immunoprecipitation and immunoblot. Results We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype ( P <0.05). On the contrary, survival analysis indicated shorter overall survival for patients with ccRCC with GSTM1-active genotype ( P = 0.026). Furthermore, patients with ccRCC with GSTM1-active genotype had significantly higher hazard ratio ( P <0.05), in analyzed regression models, compared with the carriers of GSTM1-null genotype. Finally, the presence of GSTM1:ASK1 protein-protein interaction was found in all RCC tissue samples studied. Conclusions Carriers of GSTM1-null and GSTP1-variant genotypes are in increased risk of RCC development. On the contrary, GSTM1-null genotype is associated with favorable postoperative prognosis in ccRCC. The possible molecular mechanism underlying the role of GSTM1 protein in RCC progression might be the presence of GSTM1:ASK1 protein-protein interaction. Hence, determination of GSTM1 -genotype might serve as a valuable indicator in both RCC risk assessment and postoperative prognosis.</description><subject>Carcinoma, Renal Cell - enzymology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione S-transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Kidney Neoplasms - enzymology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Prognosis</subject><subject>Renal cell carcinoma</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Survival</subject><subject>Urology</subject><issn>1078-1439</issn><issn>1873-2496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EoqXwE0A-ckkYj_PhXECogoJUxKHt2XLsSeUlay92grT_Hke7cODCxR7L7zsfzzD2WkAtQHTvdvWa4hyDrRFEXwPWAO0TdilULytshu5piaFXlWjkcMFe5LwDEI0S4jm7QIWqUYO8ZA83d_ffBH-kEJfjgbjP3ATug6MDlSMs_JDiY4h58ZZPxi4xlV9uZzKJW5pnniiY-RRak6wPcW9esmeTmTO9Ot9X7OHzp_vrL9Xt95uv1x9vK9sgLFWLSEKhM6haOcFghhFJGujsgGPjxrZzrlX9OHTT5By1gLY8EVspjUTo5RV7e8pbmvy5Ul703uetFRMorlkXGJ0SPfZDkbYnqU0x50STPiS_N-moBeiNqN7pM1G9EdWAuhAtvjfnEuu4J_fX9QdhEXw4CagM-stT0tl6CpacT2QX7aL_b4n3_2Swsw_emvkHHSnv4poK4jKNzsWg77a1blsVvQToOpS_AR48nmI</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Coric, Vesna M., M.D</creator><creator>Simic, Tatjana P., M.D., Ph.D</creator><creator>Pekmezovic, Tatjana D., M.D., Ph.D</creator><creator>Basta-Jovanovic, Gordana M., M.D., Ph.D</creator><creator>Savic-Radojevic, Ana R., M.D., Ph.D</creator><creator>Radojevic-Skodric, Sanja M., M.D., Ph.D</creator><creator>Matic, Marija G., M.D., Ph.D</creator><creator>Suvakov, Sonja R., M.D., Ph.D</creator><creator>Dragicevic, Dejan P., M.D., Ph.D</creator><creator>Radic, Tanja M., M.Sc</creator><creator>Dzamic, Zoran M., M.D., Ph.D</creator><creator>Pljesa-Ercegovac, Marija S., M.D., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma</title><author>Coric, Vesna M., M.D ; Simic, Tatjana P., M.D., Ph.D ; Pekmezovic, Tatjana D., M.D., Ph.D ; Basta-Jovanovic, Gordana M., M.D., Ph.D ; Savic-Radojevic, Ana R., M.D., Ph.D ; Radojevic-Skodric, Sanja M., M.D., Ph.D ; Matic, Marija G., M.D., Ph.D ; Suvakov, Sonja R., M.D., Ph.D ; Dragicevic, Dejan P., M.D., Ph.D ; Radic, Tanja M., M.Sc ; Dzamic, Zoran M., M.D., Ph.D ; Pljesa-Ercegovac, Marija S., M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-522e182da2853f09a9b2e3a06c92b4db56dd587b96ffdde502c58722533a32073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Carcinoma, Renal Cell - enzymology</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione S-transferase</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Kidney Neoplasms - enzymology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Prognosis</topic><topic>Renal cell carcinoma</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Survival</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coric, Vesna M., M.D</creatorcontrib><creatorcontrib>Simic, Tatjana P., M.D., Ph.D</creatorcontrib><creatorcontrib>Pekmezovic, Tatjana D., M.D., Ph.D</creatorcontrib><creatorcontrib>Basta-Jovanovic, Gordana M., M.D., Ph.D</creatorcontrib><creatorcontrib>Savic-Radojevic, Ana R., M.D., Ph.D</creatorcontrib><creatorcontrib>Radojevic-Skodric, Sanja M., M.D., Ph.D</creatorcontrib><creatorcontrib>Matic, Marija G., M.D., Ph.D</creatorcontrib><creatorcontrib>Suvakov, Sonja R., M.D., Ph.D</creatorcontrib><creatorcontrib>Dragicevic, Dejan P., M.D., Ph.D</creatorcontrib><creatorcontrib>Radic, Tanja M., M.Sc</creatorcontrib><creatorcontrib>Dzamic, Zoran M., M.D., Ph.D</creatorcontrib><creatorcontrib>Pljesa-Ercegovac, Marija S., M.D., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coric, Vesna M., M.D</au><au>Simic, Tatjana P., M.D., Ph.D</au><au>Pekmezovic, Tatjana D., M.D., Ph.D</au><au>Basta-Jovanovic, Gordana M., M.D., Ph.D</au><au>Savic-Radojevic, Ana R., M.D., Ph.D</au><au>Radojevic-Skodric, Sanja M., M.D., Ph.D</au><au>Matic, Marija G., M.D., Ph.D</au><au>Suvakov, Sonja R., M.D., Ph.D</au><au>Dragicevic, Dejan P., M.D., Ph.D</au><au>Radic, Tanja M., M.Sc</au><au>Dzamic, Zoran M., M.D., Ph.D</au><au>Pljesa-Ercegovac, Marija S., M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma</atitle><jtitle>Urologic oncology</jtitle><addtitle>Urol Oncol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>35</volume><issue>6</issue><spage>409</spage><epage>417</epage><pages>409-417</pages><issn>1078-1439</issn><eissn>1873-2496</eissn><abstract>Abstract Purpose Owing to dual functionality of cytosolic glutathione S-transferases (GSTs), they might affect both the development and the progression of renal cell carcinoma (RCC). However, the data on the prognostic value of GST polymorphism in patients with RCC are scarce. Hence, we evaluated the effect of GST gene variants on both the risk of RCC development and the postoperative prognosis in patients with clear cell RCC (ccRCC). Methods GST genotypes were determined in 305 patients with RCC and 326 matched controls, whereas the overall survival was evaluated in patients with ccRCC only. The presence of GSTM1:ASK1 protein-protein interaction in ccRCC tissue samples was analyzed by methods of immunoprecipitation and immunoblot. Results We noted an increased risk of RCC development in carriers of GSTM1-null and GSTP1-variant genotype ( P <0.05). On the contrary, survival analysis indicated shorter overall survival for patients with ccRCC with GSTM1-active genotype ( P = 0.026). Furthermore, patients with ccRCC with GSTM1-active genotype had significantly higher hazard ratio ( P <0.05), in analyzed regression models, compared with the carriers of GSTM1-null genotype. Finally, the presence of GSTM1:ASK1 protein-protein interaction was found in all RCC tissue samples studied. Conclusions Carriers of GSTM1-null and GSTP1-variant genotypes are in increased risk of RCC development. On the contrary, GSTM1-null genotype is associated with favorable postoperative prognosis in ccRCC. The possible molecular mechanism underlying the role of GSTM1 protein in RCC progression might be the presence of GSTM1:ASK1 protein-protein interaction. Hence, determination of GSTM1 -genotype might serve as a valuable indicator in both RCC risk assessment and postoperative prognosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28284893</pmid><doi>10.1016/j.urolonc.2017.02.005</doi><tpages>9</tpages></addata></record> |
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| subjects | Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Case-Control Studies Female Genetic Predisposition to Disease Genotype Glutathione S-transferase Glutathione Transferase - genetics Humans Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Middle Aged Polymorphism Prognosis Renal cell carcinoma Retrospective Studies Risk Survival Urology |
| title | GSTM1 genotype is an independent prognostic factor in clear cell renal cell carcinoma |
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