Human amniotic mesenchymal stromal cell transplantation improves endometrial regeneration in rodent models of intrauterine adhesions

Highlights • Rodent models of intrauterine adhesions were induced by mechanical injury. • The model is valuable for future regenerative and reproductive studies. • hAMSC transplantation promotes endometrial regeneration of intrauterine adhesions. • The mechanism relies on the immunomodulatory proper...

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Bibliographic Details
Published in:Cytotherapy (Oxford, England) England), 2017-05, Vol.19 (5), p.603-616
Main Authors: Gan, Lu, Duan, Hua, Xu, Qian, Tang, Yi-Qun, Li, Jin-Jiao, Sun, Fu-Qing, Wang, Sha
Format: Article
Language:English
Subjects:
Advanced Basic Science
amnion
Amnion - cytology
Animals
Cells, Cultured
Disease Models, Animal
endometrium
Endometrium - pathology
Female
Fibroblast Growth Factor 2 - genetics
Fibroblast Growth Factor 2 - metabolism
Fluorescent Antibody Technique
Humans
Interleukin-1beta - genetics
Interleukin-1beta - metabolism
Interleukin-6 - genetics
Interleukin-6 - metabolism
intrauterine synechiae
Mesenchymal Stem Cell Transplantation
mesenchymal stromal cell transplantation
Mesenchymal Stromal Cells - cytology
Other
Rats, Sprague-Dawley
Regeneration
Tissue Adhesions - pathology
Tissue Adhesions - therapy
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
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Summary:Highlights • Rodent models of intrauterine adhesions were induced by mechanical injury. • The model is valuable for future regenerative and reproductive studies. • hAMSC transplantation promotes endometrial regeneration of intrauterine adhesions. • The mechanism relies on the immunomodulatory properties of hAMSC. • hAMSC are an additional source for future stem cell research on injured endometria.
ISSN:1465-3249
1477-2566
DOI:10.1016/j.jcyt.2017.02.003