Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures

Highlights • GABAA -α1 was persistently enhanced in the hippocampus following hyperthermic seizure. • CR expression was transiently enhanced at epileptogenic period by recurrent seizure onset. • fEPSP and PS latency significantly declined at recurrent seizure time period. • PS amplitude and excitabi...

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Bibliographic Details
Published in:Brain research bulletin 2017-05, Vol.131, p.25-38
Main Authors: Yu, Yeon Hee, Lee, Kahyun, Sin, Dal Sik, Park, Kyung-Ho, Park, Dae-Kyoon, Kim, Duk-Soo
Format: Article
Language:English
Subjects:
Animals
Calretinin
Disease Models, Animal
Epilepsy - metabolism
Epileptogenesis
Excitatory Amino Acid Agents - metabolism
Excitatory Postsynaptic Potentials - drug effects
Febrile seizure
Field excitatory postsynaptic potential
GABA Agents - metabolism
GABA Antagonists - pharmacology
GABAA-α1
Glutamic Acid - metabolism
Hippocampus - physiopathology
Interneurons - physiology
Neurology
Neurons - metabolism
Paired-pulse response
Rats
Rats, Sprague-Dawley
Receptors, GABA-A - metabolism
Receptors, GABA-B - metabolism
Seizures - metabolism
Seizures - physiopathology
Seizures, Febrile - physiopathology
Synaptic Transmission - drug effects
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Summary:Highlights • GABAA -α1 was persistently enhanced in the hippocampus following hyperthermic seizure. • CR expression was transiently enhanced at epileptogenic period by recurrent seizure onset. • fEPSP and PS latency significantly declined at recurrent seizure time period. • PS amplitude and excitability ratio were enhanced following FS. • Febrile seizure is contributed to a maximal potential in fEPSP.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.02.009