Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up

• Published in: Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2017-04, Vol.69, p.212-220
• Main Authors: Fernandez, Mariana F., Pumarega, Jose, Porta, Miquel, Molina-Molina, Jose Manuel, Arrebola, Juan P., Olea, Nicolas
• Format: Article
• Language: English
• Subjects: Adipose Tissue - metabolism; Adult; Aged; Aged, 80 and over; Body Burden; breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - surgery; cancer treatment; chemotherapy; Environmental Pollutants - metabolism; estrogen receptor tumors; Estrogens - metabolism; Female; follow up; Humans; Hydrocarbons, Chlorinated - metabolism; Middle Aged; Postoperative Period; TEXB; total effective xenoestrogen burden
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/j.reprotox.2017.03.007

•Total effective estrogenic burden (TEXB) reflects the combined effect of xenoestrogens.•TEXB was measured in breast cancer women at surgery and during 18-month follow-up.•Breast adipose tissue was collected at surgery and abdominal tissue during follow-up.•Median TEXB concentrations significantly increased during follow-up.•Tumor characteristics (ER positivity) and age were related to TEXB values. We aimed to assess changes in the total effective xenoestrogen burden (TEXB) −a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women. TEXB values significantly increased over follow-up (p